302 STATE BOARD OF AGRICULTURE. 



transverse folds of the mucosa are congested and there is some hyper- 

 trophy of the left lateral portion of the second fold. Body of uterus is 

 four centimeters in length. There are about thirty cubic centimeters of 

 a sero-purulent exudate in uterine cavit3\ The mucosa of body is not 

 uniform in color. Upon close examination, areas are seen in which there 

 are small irregularly shaped grayish colored foci varjang in size from 

 that of a pinpoint to one millimeter in diameter. The mucosa of the 

 left horn is more uniform in color except at its posterior end where the 

 appearance is similar to that of the body. The color of mucosa is of a 

 lighter gray color than is normally seen in a cow that has calved. The 

 cotyledons vary in size from three to six millimeters and are of a grayish 

 yellow color. Both oviducts are apparently normal. The left ovary is 

 four and one-half centimeters in diameter and contains a cyst-like struc- 

 ture one and one-half centimeters in diameter. Left ovaiy is four centi- 

 meters in diameter. B. coli communior was obtained from exudate in 

 uterine cavity. Cultures from the deeper layers Avere negative. 



Histological examination: The epithelium of the cervical mucosa is 

 not uniform in appearance. In places it is normal, in others the cells are 

 swollen and many of them have lost their nuclei. Desquamation is ob- 

 served in places. Many of the sub-epithelial capillaries are filled with 

 blood and small sub-epithelial hemorrhages are seen in jjlaces. Local 

 areas of edema are also observed. In places there are marked collections 

 of cells under the epithelium. Here endothelial cells and lymphocytes 

 predominate although there are a few polymorphonuclears and erythro- 

 cytes observed. 



The mucosa of the uterine body varies from one to three millimeters 

 in thickness and is covered by an epithelium sixteen to thirty microns in 

 height. Numerous leucocytes are seen in the process of passing through 

 the epithelium. In places the ej)ithelial cells are cloudy and the nuclei 

 very faintly stained. The sub-epithelial cellular zone is not sharplj^ 

 differentiated but blends gradually with the deeper portion of the stroma. 

 There is a marked leucocytic infiltration of the sub-epithelial zone. There 

 are numerous collections of the leucocytes into groups explaining the 

 appearance seen in the macroscopic examination. The intergiaudular 

 tissue is thickened but partakes more of the nature of adult connective 

 tissue. Only in places is there evidence of active proliferation. The 

 glandular changes are marked. Many of the glands are apparently nor- 

 mal but many others show marked degenerative and disintegrative 

 changes of the epithelium with round cell infiltration of the gland 

 luminae. 



Summary: Of the eleven cases presented here, all except numbers 990 

 and 17 were clinically sterile. Number 99G was slaughtered because of 

 a peri-uterine abscess and number 17 was slaughtered because of abort- 

 ing some seven weeks before. The anatomical alterations of the uterine 

 mucosa vary in the different animals from slight fibrous thickening of 

 the transverse cervical folds with no apparent alterations of the corporal 

 and cornual mucosae (case number 18) to an atrophic endometritis 

 (cases number 23 and 25). The lesions observed in varjdng degrees in 

 the different cases are mucoid degeneration of the superficial epithelium, 

 local and dift'use fibrosis of the uterine mucosae, leucocytic infiltration 

 of the stroma and gland luminae and degeneration and disintegration 

 of the glandulnr epithelium with diminution in the number of glands. 



