1S8 



ANNUAL REPORT OF THE 



Ofif. Doc. 



In 1905 to 1909 inclusive, sections of the medulla oblongata and 

 ganglion, including one of the sympathetic ganglion and pleviform 

 ganglion of the pneumo-gastric nerve were examined for proliferation 

 changes with the following results: 



Medulla Oblongata, 337, _ 



(Babes Proliferation Changes), 



Positive Cases. 



180 (71.7%)+* 



m (27.5%)— 



2 ( 0.8%)S 



86 

 Negative Cases. 



SO (93.0%)— 

 6 ( 5.8%)- 

 1 ( 1.1%)S 



Sympathetic ganglion, 242, 

 (Van Hehuchten and Nelis), 

 (Proliferation Changes), 



171 

 Positive Cases. 



13» (77.6%) + 



30 (16.0%)— 



2 ( 5.8%)S 



71 

 Negative Cases. 



66 (92.9%)— 

 3 ( 4.2%) + 

 2 ( 1.1%)S 



Plexiform Ganglion, 468, 



360 



Positive Cases. 



3.57 (99.1%) + 

 ( %)- 

 3 (00. 8%) S 



108 

 Negative Cases. 



71 (65.T%(- 

 14 (12.9%) + 

 23 (21.2%)S 



*+=Positive. — =Negative. S=Suspicious. 



Babes "rabic tubercle" were not seen in 27.5 per cent, of the sections 

 of the Medulla oblongata examined from animals with rabies and in 

 5.8 per cen* "rabic tubercles" were demonstrated in the medulla 

 oblongata of dogs proven to have been free of rabies. The changes 

 of Van Gehuchten and Nelis in the sympathetic ganglion were seen 

 in 77.6 per cent, of the actual cases of rabies, and in 4.2 per cent, of 

 the ganglion of animals free of rabies. The changes in the plexiform 

 ganglion of the positive cases were found in 99.1 per cent., and in not 

 a single instance of all the cases considered rabid did these ganglionic 

 changes fail to show themselves. That similar changes are seen in 

 the plexiform ganglion of animals not rabid is shown in that in 

 12.9 per cent, of the negative cases similar changes were found. The 

 changes in the plexiform ganglion are better developed the longer the 

 animal is permitted to live after beginning to show symptoms of 

 rabies. 



NEGRI BODIES 



The bodies demonstrated by Prof. Adelchi Negri of Pavia Univer- 

 sity in 1903 in the nerve cells of the brain and spinal cord of animals 

 dead of rabies and knoAvn as Negri bodies, are now held of the 

 highest value in the diagnosis of rabies, and the bodies are looked 

 upon as the probable cause of rabies. They have as yet not been 

 demonstrated in any other diseases. Bodies such as vacoules and 

 granules are seen in the nerve cells of the normal animal or in 

 those dead of one cause or another but these bodies cannot be mis- 

 taken for the Negri body whipji has definite morphological character- 



