SYMPATHOMIMETICS AND CENTRAL STIMULANTS 



Fig. 4b. Crystallization of dZ-amphetamine hydrochloride, (volatility test), "map formation", 

 with crossed nicols. 66X. 



— , no result 



c, crystals are obtained 

 C, a major crystal test 

 a, amorphous 



d, precipitate collects in drops which do 

 not form crystals, or only after a consider- 

 able time 



r, reduction occurs (crystals of metallic 

 gold form). The reduction is sometimes 

 fairly prompt and sometimes slow. 



( ) parentheses indicate that the par- 

 enthetical result may not occur; usually 

 used for (c) when, because of slow foimation 

 or lack of sensitivity, crystals may not be 

 obtained. 



/ change of conditions. In columns 6, 8, 

 and 10, when direct addition of the reagent 

 to the solid does not give good results (gen- 

 erally because of the instant formation of 

 insoluble masses or coating), some of the 

 substance is dissolved in a little water and 

 the reagent added. The result is given follow- 

 ing the /. In columns (7), (9), and (11), the 

 result following the / is that noted after 

 reinversion of the slide with the hanging 

 drop, and at least partial evaporation of 

 water from it. 



In Fig. 5a, b, c are reproduced additional 

 examples of microcrystals formed by com- 

 pounds of this type (benzylephedrine, cyclo- 



FiG. 4c. Deposit of d- + dZ-amphetamine hy- 

 drochloride. Volatility test, substance caught in a 

 drop of dilute HCl and the drop evaporated, as 

 seen with crossed Nicols. 66 X. 



II. a volatile base of decomposition is 

 evolved. 



III. at room temperature the substance 

 shows only a slight volatility, unchanged. 



IV. the substance is readily volatile with 

 water vapor at room temperature. 



In the table for sympathomimetics and 

 central stimulants the following symbols are 

 used: 



69 



