ELECTRON MICROSCOPY 













Fig. 1. "Pure" Nephrosis. Very little changes in the endothelial cells (End). The epithelial cell is 

 swollen with several vacuoles and partial destruction of the foot processes. 



the epithelial cells, i.e., toward the cavity of 

 Bowman's capsule. Within the protrusions a 

 fine spongy or felt-like structure with inter- 

 woven filaments was observed. The thick- 

 ness of the filaments was calculated as 30-40 



o 



AU. There were no pores in the altered base- 

 ment membranes. Earlier observations with 

 the Ught microscope indicated that amyloid 

 is deposited between the basement mem- 

 brane and the endotheUum. The authors 

 therefore concluded that the changes in the 

 basement membranes w^ere probably not due 



to amyloid but to an increased leakage of 

 protein through the capillary walls. 



Human Amyloidosis. A case of renal 

 amyloidosis secondary to chronic osteomye- 

 litis was reported by Geer et al. (1958). The 

 glomerular capillary basement membranes 

 were uniformly thickened with a diameter of 

 approximately 0.5 micron. Large masses of 

 material with the same structureless appear- 

 ance as the basement membrane but with 

 less density were observed in the basement 

 membranes in the "basilar" portions of the 



210 



