I9I3] I' K. Phelps 93 



Bureau of Chemistry, U. S. Dep't of Agriciilture, Washington,, 

 D. C.) Tin, in the form of a double salt, was given subcutaneously 

 and by mouth to different animals. Analyses of the urine and feces, 

 and of the contents of the stomach and intestines, which were made 

 gravimetrically and volumetrically, gave the following results : 

 After the subcutaneous administration 5-15 percent was eHminated 

 in the urine in 24-48 hours. The feces of the corresponding period 

 contained much smaller amounts. The contents of the stomach and 

 intestines, and the feces, contained as much or more tin than the 

 urine. In some animals the amount of tin eliminated by the kid- 

 neys was smaller than that recovered from the gastro-intestinal 

 contents and feces. 



Analysis of the skin indicated the presence of 20-25 percent of 

 the amount of tin injected. 



When double salts of tin were given by mouth, small quantities 

 of it were found in the tissues and in the urine, indicating that 

 absorption from the gastro-intestinal canal takes place to a very 

 small extent only, and may be insignificant in some animals. 



The amount of tin found in the liver of rabbits at the end of 

 48 hours varied between 0.6 and 10.8 percent. The kidneys of 

 such animals contained quantities varying between 1.6 and 8.2 per- 

 cent of the amount of tin injected. Experiments on the absorp- 

 tion of the salt from the blood indicate that 85-95 percent may dis- 

 appear in 2—3 hours af ter intravenous injection of 70-200 mg. of tin. 



The fate of creatine and Creatinine when administered to 

 rabbits.^ V. C. Myers and M. S. Fine. (Laboratory of Patho- 

 logical Chemistry, New York Post-Graduate Medical School and 

 Hospital.) When creatine is administered subcutaneously to 

 rabbits, in amounts varying between 50 and 100 mg. per kg. of body 

 weight per day, 25-80 percent, depending upon the amount given, 

 reappears in the urine unchanged, 2-10 percent is eliminated as 

 Creatinine, and about 15 percent is retained by the muscle. If intro- 

 duced in small amounts, as much as 50 percent may be metabolised. 

 We are inclined to attach considerable significance to the slightly in- 

 creased excretion of Creatinine as indicating the metabolic relation- 

 ship between these two substances. The creatine content of the 



8 Myers and Fine: Jour. Biol. Chetn., 1913, xvi, p. 169. 



