3IO Proceedings Cokimhia Biochcmical Association [Jan. 



about 600 c.c. of ether, the Solution divided into twelve equal parts 

 and each twelfth portion, after transference to a rubber Condom, 

 supported in about 250 c.c. of ether in a glass-stoppered bottle. 

 The dialysate was removed daily and fresh ether substituted. The 

 volumes in the bags increased daily to the end. The ether in the 

 mixed dialysates (a total of 8 liters) was eliminated by evaporation 

 before an electric fan, The lipin residue (360 grams; 90 percent) 

 looked like the original butter but was softer. The undiffused 

 lipin mass from the ether in the bags (40 grams from 2500 c.c.) 

 resembled the original butter but was harder. At the conclusion 

 of the experiment the rubber bags were found, with the aid of in- 

 diffusible pigments, to be free from mechanical imperfections. 



The massiveness of the main product indicated, in an impressive 

 way, the ease, rapidity and completeness with which some lipins 

 diffuse from ether through rubber into ether. 



116. A further study of the biochemical origin of sulfo- 

 cyanate.^^ Max Kahn and William J. Gies. New experiments 

 on dogs, involving determinations of the amounts of sulfocyanate 

 in the blood, some of the tissues, gastro-intestinal contents, the 

 urine and feces, after (a) administration of acetonitril, mandelic- 

 acid nitril, amygdalin, glycocol, alanin and leucin; (&) after fasting 

 and overfeeding with protein; (c) and after perfusion of blood, 

 with and without acetonitril, through the liver, Warrant the follow- 

 ing general conclusions : 



Sulfocyanate arises in the body from proteins and other sub- 

 stances that yield — CN and — SH radicals. Its quantity in any 

 part of the body appears to depend primarily upon the available 

 metabolic supply of — CN radicals. 



The liver appears to be the chief site of sulfocyanate synthesis. 

 The process of production in the liver seems to be essentially one of 

 detoxification (defense) prior to excretion of sulfocyanate in bile 

 and urine, as in the case of the conversion of indol into indican and 

 the urinary elimination of the latter. 



The radicals involved in the production of sulfocyanate are evi- 

 dently of both exogenous and endogenous derivation under ordi- 

 nary circumstances. 



^^ Conducted under the auspices of the Dental Society of the State of 

 New York. See Dental Cosmos, 1914, Ivi, p. 175. 



