I9I4] 



Carl P. Sherwin and Philip B. Hawk 



419 



throughout. The " repeated " fast was 105 days in length, during 

 which the indican values were much lower than during the initial 

 fast. There was an absolute absence of indican in all urine passed 

 during the last 48 days of the "repeated" fast, i. e., after the s/th 

 fasting day. The finding of diminished intestinal putrefaction as 

 a result of "repeated" fasting is in hne with other observations 

 f rom our laboratory which have shown that " repeated fasting " is 

 accompanied by greater resistance ; a less rapid loss in body weight ; 

 less pronounced protein catabolism; a general physical and mental 

 improvement. 



TABLE 2 



Data pertaining to a fast of 105 days duration 



Days 



Average daily 

 urine volume 



Potassium permanganate 

 Solution used in titrating 

 40 c.c. of clarified sample 



Total potassium perman- 

 ganate Solution used for 24 

 hr. average urine volume 



Indican 



Output per day 



expressed in mg. 



Normal pre-fasting period (4 days): 700 c.c. of water ingested per day 



1-4 



504 



3-26 



45-2 



11.9 



Fasting period (105 days): 700 c.c. of water ingested per day 



BIBLIOGRAPHY 



1. Sherwin and Hawk: Jour. Biol. Chem., ii, 169, 1912. 



2. HowE, Mattill and Hawk: Ibid., 11, 103, 1912. 



3. HowE and Hawk: Jour. Amer. Chem. Soc, 33, 215, 1911. 



4. Maillard: Zeit. f. physiol. Chem., 41, 32, 1904. 



5. Sherwin and Hawk: Jour. Amer. Chem. Soc., 36, 1779, 1914. 



6. Müller: Virchoii/s Arch, p. 131, Supplement, 1893. 



7. Hattrem and Hawk: Arch. Int. Med., i, 610, 1911. 



8. HowE and Hawk : Reported before the American Physiological So- 



ciety, Baltimore, 1911 ; not abstracted. 



