igii] Jacob Rosenhloom yy 



hol, but this is also true of artificial mixtures of protein with leci- 

 thin. Hoppe-Seyler supposed lecithin to be combined with protein 

 in the vitellin of Q.gg yolk. Beyond the fact, however, that the leci- 

 thin in the yolk could not be extracted from ovovitellin by ether, 

 but was extracted by hot alcohol there is no evidence to show that 

 lecithin and protein form definite chemical combinations in tgg yolk. 

 Hoppe-Seyler also regarded " ichthulin " as a lecithalbumin. 



Osborne and Campbell found in tgg yolk a substance that was 

 soluble in salt Solution and which consisted of a mixture of Com- 

 pounds of protein matter with lecithin. These Compounds con- 

 tained from 15 to 30 per cent. of lecithin and they thought these 

 substances might be called lecithin nucleovitellin. It is also inter- 

 esting to note that Hoppe-Seyler believed that Chlorophyll is a leci- 

 thin derivative in which the fatty acid radicals are replaced by 

 chromophoric groups of acid character. These groups he called 

 chlorophyllanic acid. However, Schunck and Marchlewski, and 

 Stoklasa, have thrown doubt on this assumption. 



Some of the phospholipins in which the relation of nitrogen to 

 phosphorus is 2: i, i. e., the so-called diamino-monophosphatids, 

 are soluble in ether, but cannot be directly extracted from cells by 

 ether. They can be withdrawn by ether after preliminary treat- 

 ment of the tissue with alcohol. It is therefore possible that these 

 substances exist in the tissues in combination with protein. This 

 view is strengthened by the fact that tissues contain a certain 

 amount of fat, which can only be extracted after peptic digestion. 



Joachim has described a Compound of lecithin with Pseudoglob- 

 ulin from a chylous fluid. Brown and Morris, in a study of 

 anemia produced in dogs poisoned with monoacetyl-phenylhydra- 

 zine, observed the presence of a substance in the serum which 

 gave the serum a milky appearance, but on addition of various fat 

 solvents, no fatty matter could be dissolved out. However, after 

 the addition of a small amount of ammonium Oxalate to precipitate 

 the calcium, a large amount of fatty matter could then be extracted 

 from the serum by means of ether. Brown and Morris have there- 

 fore concluded that the fat was combined in the nature of a calcium 

 protein-compound. 



Compounds of lipins with carbohydrates. Drechsel de- 



