BiocHEMiCAL Bulletin „^^^„^ 



NEW YORiC 



^ botanical 



Volume I DECEMBER, 191 1 No. 2 üaküen. 



A REVIEW OF THE HISTORY OF BENCE JONES 

 PROTEIN AND MULTIPLE MYELOMA 



JACOB ROSENBLOOM 



(Laboratory of Biological Chemistry of Columbia University, at the College of 



Physicians and Surgeons, New York) 



I. INTRODUCTION 



In connection with an experimental study of the origin of Bence 

 Jones protein, I had occasion to prepare a review of our knowledge 

 of this important substance.^ That review is included in the present 

 paper, 



It was my intention, before beginning the experimental investi- 

 gation of Bence Jones protein, to make a Hst of all the known 

 cases of myeloma and Bence Jones proteinuria with the characteris- 

 tics of each, but this was found to have been done by Anders and 

 Boston (i), wlio recorded cases prior to 1903 and gave a report of 

 three new cases : by Weber (2), who recorded 28 cases prior to 1904 

 and gave the history of ten more cases; by Moffat (3), who re- 

 corded 39 cases prior to 1905; and by Permin (4) who recorded 40 

 cases prior to 1907. Decastello (5), in a recent paper, described 

 two more cases and made an analysis of those previously recorded. 



In 1847 Bence Jones (6) presented before the Royal Society 

 of London, a paper " On a New Substance Occurring in the Urine 

 of a Patient with Mollities ossium," in which he described, for the 

 first time, the substance since known as the Bence Jones protein. 

 Later (7) he described several properties of this substance, and gave 

 the results of a study of it in his report on Mollities ossium. The 



^^ ^ Rosenbloom : A contribution to the study of the nature and origin of the 



CTi Bence Jones protein. Dissertation. Pp. 64. Columbia University, 1909. 



'^^ 161 



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