102 Bence Jones Protein — Multiple Myeloma [Dec. 



Bence Jones protein was rediscovered and described by Kühne (8) 

 in 1869. It has since been the subject of many investigations, 

 especially by Matthes (9), Ellinger (10), Magnus-Levy (11), 

 Jochman and Schumm (12), Bradshaw (13), Moffat (14) and 

 Simon (15). Magnus-Levy (11), and also Grutternick and de 

 Graaf (27), have succeeded in obtaining Bence Jones protein in 

 crystalline form. 



Does Bence Jones protein occur in bone? Ellinger (10) suc- 

 ceeded in obtaining Bence Jones protein in small amounts from 

 diseased bone marrow. Hopkins and Savory (16) could not find 

 the substance in the bone marrow from the cases they studied. 

 Virchow (17) found it in the bone marrow in cases of osteomalacia, 

 so-called. Barr (18) could not find in the bone marrow substance 

 of bone tumor, any trace of Bence Jones protein or of enzymes. 

 Wood (19) Claims to have separated Bence Jones protein from a 

 portion of bone affected by multiple myeloma, but could not obtain 

 it from the bone marrow in any other portion of the body of the 

 patient. Askanazy (20) was able to demonstrate its presence in 

 the bone marrow of a case of multiple myeloma but was unable to 

 find it in blood from this patient. Löwy (21) could not detect a 

 trace of Bence Jones protein in the marrow of the affected ribs and 

 humerus of Kalischer's case. Weber (22), however, was able to 

 prove the presence of a substance giving reactions similar to those 

 of Bence Jones protein, in the vertebrae and ends of the femur in 

 a case of multiple myeloma, but he could not detect this substance 

 in any other tissue or organ. Bruce, Lund, and Whitcomb (23) 

 found, in a case of multiple myeloma, that the fluid obtained from 

 an affected bone, after sawing through it, gave the reactions of the 

 Bence Jones protein. Ribbinik (24) could not find Bence Jones 

 protein in the bone marrow substance of the case studied by him. 

 Fleischer (25), however, has found a substance giving the reactions 

 of Bence Jones protein in normal bone marrow. In a case of 

 Weber's (2), microscopic section of some of the organs and the new 

 growth in multiple myeloma showed the presence of a homogeneous 

 hyalin substance which he thought might possibly be Bence Jones 

 protein. Bradshaw and Warrington (26), in an analysis of a rib 

 affected with multiple myeloma, found the relation of organic and 

 inorganic substances to be practically normal. 



