191 1] Jacob Rosenbloom 163 



Digestive products of Bence Jones protein. Moitessier (28) 

 on subjecting Bence Jones protein to gastric digestion obtained meta- 

 protein, primary proteoses (except heteroproteose), secondary pro- 

 teoses and peptone. After peptic digestion of Bence Jones protein, 

 Simon (15) could not detect primary proteoses among the products 

 formed, but found deiiteroproteose "B" (Pick) and peptone "A" 

 (Pick). Coriat (36) foimd Bence Jones protein digestible in arti- 

 ficial pancreatic jiiice. 



General chemical nature of Bence Jones protein. Magntis- 

 Levy (11) published resiilts of a study of the digestive products of 

 Bence Jones protein, its reaction and content of amid, diamino and 

 monoamino nitrogen. Huppert (29) recorded results of various 

 elementary analyses that have been made of Bence Jones protein. 

 Abderhalden and Rostoski (30) made an analysis of Bence Jones 

 protein to determine the amounts of the various amino acids con- 

 tained. Hopkins and Savory (16) found that Bence Jones protein 

 yields all the amino acids characteristic of typical protein, and 

 that it contains a large proportion of aromatic radicals. Reach (31 ) 

 gave the results of an analysis of Bence Jones protein in terms of 

 its nitrogen partition. Gross and Allard (37) administered 10 

 grams of Bence Jones protein to an alkaptonuric subject, with other- 

 wise unaltered diet. There was a large increase in the Output of 

 homogentisic acid, which suggested to Gross and Allard that Bence 

 Jones protein is rieh in aromatic radicals. 



Bence Jones protein in urine. Zuelzer (32) obtained Bence 

 Jones protein in the urine of dogs poisoned with pyrodin (mono- 

 cetyl-phenylhydrazine), a strong hemolytic agent. Stokvis (33) 

 found Bence Jones protein in the urine of dogs after its intravenous 

 or rectal injection. Matthes (9) also found it in the urine of a dog 

 after the subcutaneous injection of Bence Jones protein. Ellinger 

 (10) introduced 5 grams of Bence Jones protein intravenously 

 into a dog, but the urine yielded no precipitate with (NH4)2S04, 

 although the liquid gave a strong biuret reaction suggestive of pep- 

 tone (Kühne), which may have been derived from the injected 

 material. Rosenbloom (R) has studied a case in which the Bence 

 Jones protein was spontaneously precipitated from the urine. 



Allard and Weber (34) found that the Röntgen ray treatment 



