164 Beiice Jones Protein — Multiple Myeloma [Dec. 



of the bone tiimor had 110 effect on the urinary Output of Bence 

 Jones protein. Voit and Salvendi (35) reported a case in which 

 diet appeared to modify the elimination of Bence Jones protein, but 

 Weber observed that changes of diet had no influence on its elimina- 

 tion in his case of multiple myeloma. Hopkins and Savory (16) 

 found that the amount of excreted Bence Jones protein was pro- 

 portional to the extent of metabolism rather than to any other 

 factor. 



Bence Jones protein in blood and lymph. Ribbinik (24) and 

 Askanazy (20) could not find Bence Jones protein in the blood of 

 patients with multiple myeloma. EUinger (10) obtained it from 

 ascitic fluid. Coriat (36) found Bence Jones protein in a pleural 

 effusion from a patient suffering from multiple neuritis associated 

 with extreme tenderness of the ribs, although the protein was 

 absent from the urine. Rostoski (38) found that the method of 

 " precipitin " detection fails to distinguish Bence Jones protein from 

 various proteins of human origin. Donati and Satta (39) have 

 shown that serum albumin, serum globulin, edestin, egg albumin, 

 milk, and milk serum, inhibit the hemolytic action of sodium gly- 

 cocholate and sodium oleate, whereas ovo-albumin, Bence Jones pro- 

 tein, and casein, accelerate the hemolysis. Borchart and Lippmann 

 (40) found that after feeding Bence Jones protein to fasting dogs, 

 it could be detected in serum from the animals by the precipitin test 

 and in samples of their blood by chemical tests. 



IL PROTEOSURIA AND BENCE JONES PROTEIN 



Proteoses have been found in the urine under many conditions, 

 usually in minute quantities and as temporary constituents of the 

 urine during the course of specific fevers, inflammatory processes, 

 and other diseases. The urinary proteoses present different char- 

 acteristics from those of Bence Jones protein, however, and must 

 be sharply distinguished from the latter. Among the most promi- 

 nent of these differences between Bence Jones protein and ordinary 

 proteoses, the following may be indicated in terms of Bence Jones 

 protein : 



1. Soluble in water (different from heteroproteose). 



2. Coagulated at low temperatures (unlike other proteoses col- 



