igii] Jacob Rosenbloom 165 



lectively), thoiigh elastoses are precipitated by heating their aqiieous 

 Solutions but redissolve as the temperatiire falls. 



3. Coiivertible into metaproteins (unlike other proteoses collec- 

 tively). 



4. Digested by pepsin-HCl, yields protoproteose (unlike all pro- 

 teoses). 



5. Not acted upon by erepsin (different from proteoses). 



6. Excreted in larger proportions than the proteoses. 



7. Does not dialyze through parchment paper (different from all 

 soluble proteoses). 



8. Not precipitated from saline Solution by dialysis (different 

 from several proteoses). 



III. THEORIES REGARDING THE ORIGIN AND THE NATURE 

 OF BENCE JONES PROTEIN 



Proteose relationships. Kühne (8) belle ved that Bence Jones 

 protein is closely related to heteroproteose on account of the fact 

 that the pure substance, after its precipitation from its Solution by 

 heating, redissolves with further elevation of the temperature. 

 Huppert (29) also thinks the protein is a heteroproteose. De- 

 chaunne (41) considers it a mixture of at least three proteins or 

 groups of proteins, probably proto- and dysproteoses, and a sub- 

 stance Hke heteroproteose. Kühne and Chittenden (43) found 

 that, on the basis of elementary composition, Bence Jones protein 

 resembled heteroglobulose. Neumeister (42) showed that Bence 

 Jones protein is not heteroproteose. He did not believe that there 

 is any relation between digestive conditions and the presence of 

 this substance in the urine. He thought rather, that it is a sub- 

 stance of a peculiar kind and quite unlike any other that had hith- 

 erto been described. Matthes (9), was of the same opinion as 

 Neumeister. 



Possible derivation from blood proteins. Simon (15) thinks 

 Bence Jones protein is formed from the serum globulins, perhaps 

 by an enzymotic action of the tumor cells, and that once pro- 

 duced, it is rapidly excreted by the kidneys as are all foreign pro- 

 teins. Kühne and Chittenden (43) suggest that it may arise from 

 serum globulin. Coriat (36) also thinks it might be formed from 



