512 Biochemical News, Notes and Comment [Mar. 



II. PHARMACOLOGICAL LABORATORY, BUREAU OF CHEMISTRY, 

 U. S. DEPARTMENT OF AGRICULTURE 



The pharmacological laboratory of the Bureau of Chemistry 

 was organized by order of the Secretary of Agriculture on June 

 22, 1908, for the purpose of testing the action of drugs and drug 

 products. At first it occupied quarters in a private house near the 

 Bureau of Chemistry, but in February, 1910, the Bureau of Chem- 

 istry moved to its new quarters, where the pharmacological labora- 

 tory comprises a room for chemical work, an operating room for 

 physiological work, two rooms for animals, and an office for the 

 chief. 



The laboratory is well equipped at present for the study of the 

 action of drugs and other substances, and their effects on man and 

 animals. Besides much routine testing (which is not published) 

 the workers in this laboratory have conducted investigations on 

 bleached flour and on the effects of caffein, the various alcohols 

 and other Compounds. 



The pharmacological laboratory was organized under the per- 

 sonal direction of Dr. William Salant, who has been its chief from 

 the beginning. The following papers have been presented from this 

 laboratory by Dr. Salant and his associates. 



1908. William Salant: The necessity for animal experimenta- 

 tion in determining the purity and strength of medicinal prepara- 

 tions; Proceedings of the Twenty-fifth Annual Convention of the 

 Association of Official Agriciütitral Chemists, Biil. 122, Bureau of 

 Chemistry, U. S. Department of Agriculture. 



1909. William Salant: The comparative toxicity of ethyl and 

 amyl alcohol and their effects on blood pressure; Proceedings of 

 the Society for Experimental Biology and Medicine, vi, p. 134. — 

 W. O. Emery and William Salant : On the decomposition of cafTein 

 in the liver; Ihid., vi, p. 132. 



1910. William Salant: The toxicity of amyl acetate; Ihid., 

 vii, p. 154. — William Salant and W. O. Emery: The elimination 

 of caffein in the bile; Ibid., vii, p. 155. — William Salant and J. B. 

 Rieger: Caffein tolerance; Journul of Pharmacology and Experi- 

 mental Therapeutics, i, p. 572 (Proc. Amer. Soc. Pharm. Exp. 



