208 



Biological Stains 



T25 ACRIFLAVINE C. I. NO. 790 



Synonym: Trypaflavine. Flavine. 



H H 

 CH3 CI I / 



11— N \ / N— H 



H I J 1 f CI 



\/~C=\/ 



H 



C14H15N3CI2; Mol. Wt. 296.198 

 {A basic dye) 



This yellow dye is one of those developed by Ehrlich for its 

 therapeutic value. It is marketed at present as a disinfectant. 

 It is employed as a bacteriostatic agent by Churchman (1927) 

 mixed with methyl and crystal violets under the name of "acri- 

 violet." Acriflavine has little use as an ordinary stain, but is 

 coming to be employed to some extent as a fluorochrome; see 

 Levaditti et al (1940), Metcalf and Patton (1944). 



t30 



NEUTRAL ACRIFLAVINE 



Synonyms: Neutral trypaflavine. Eafl^vine. 



Gonacrin. 



NH. 



CHj CI 



NH, 



Neutroflavine. 



C 

 H 



C14H14N3CI; Mol. Wt. 259.733 



This dye finds use as a disinfectant. It is said to be less irritat- 

 ing than acriflavine, because it is neutral. 



t35 



H2N 



PROFLAVINE 



\ _N^/\_NHo-H.2S04 



C. I. NO. 790 



H 



C13H12N3SO4; Mol. Wt. 306.310 

 (A basic dye ordinarily supplied as the sulfate) 



Like the very similar acriflavine, this is used primarily as a 

 disinfectant. It has been called for by Rogers (1940) as an agent 

 for inhibiting sulfate-reducing bacteria. 



