Xanthene Dyes 209 



t40 ATABRINE :- Q -l.«- vu»^C/i'*'*^j|^ 



Synonym: Atehrine (in Germany). 



NH-CH(CH3)CHoCH2CH2N(C2H5)2 



CH30_/X_C_. 



I I 



C23H31N3O; Mol. Wt. 365.502 



This is a yellow compound used primarily for its medicinal 

 value (as an antimalarial agent). It shows fluorescence in ultra- 

 violet light, and has been called for by Metcalf and Patton (1944) 

 as a fluorochrome in insect histology. 



Atebrine and a few other acridine antimalarials are among the 

 dyes which Lewis and Goland (1948) have found to stain and to 

 retard tumors in mice. 



t45 PHOSPHINE C. I, NO. 793 



Synonyms: Leather yellow. Xanthin. 



A mixture of nitrates of chrysanilin, and probably some of its 

 higher homologs, chrysanilin having the following formula: 



H NO3 



\ 



C19H10N2O2; Mol. Wt. 348.350 

 {A basic dye; principal absorption in the neighborhood of 



This dye has been used (in 1% solution) by Schumacher (1922) 

 following methylene blue (1% phenolic solution) to stain bacterial 

 nucleins and nucleoproteids yellow while the free or unbound 

 nucleic acid is green. Metcalf and Patton (1944) employ phosphine 

 3R, one of the redder shades of this dye, as a fluorochrome in the 

 study of insect histology by fluorescence microscopy. 



