252 ANNUAL REPOETS OF DEPAETMENT OF AGPilCULTURE. 



Various papers reporting the above-mentioned and other work 

 were published, some in the department series and others in outside 

 journals. 



The index catalogue of medical and veterinary zoology has been 

 continued and preparation has been made for publishing in coopera- 

 tion with the United States Public Health Service additional parts 

 of this highly valuable work. 



DIVISION OF VIRUS-SERUM CONTROL. 



The regulatory work under the virus-serum-toxin act of 1913 has 

 been continued by the Division of Virus-Serum Control under the 

 supervision of Dr. D. I. Skidmore, chief. This work consisted of 

 the issuance of licenses to establishments producing veterinary 

 biological products intended for sale in interstate commerce; the 

 inspection of such establishments as to sanitary conditions and 

 methods of production ; the supervision of the production and testing 

 of products, and the issuance of permits for the importation of 

 veterinary biological products from abroad. It also involved the 

 consideration and disposal of claims made by firms producing alleged 

 remedies for hog cholera and other swine diseases. 



At the close of the year 95 establishments were operating under 

 licenses, as compared with 91 at the end of the preceding year. 

 During the year 3 establishments discontinued operations and 7 new 

 establishments began operations under licenses. Twenty licenses 

 were terminated without prejudice, most of them being reissued 

 later for such products as the firms desired to continue to produce. 

 At the close of the year there were 60 licensed establishments pro- 

 ducing only anti-hog-cholera serum and hog-cholera virus, 28 pro- 

 ducing other biologies only, and 7 producing both of the foregoing 

 classes of products. Seventy-five distinct classes of biological prod- 

 ucts other than anti-hog-cholera serum and hog-cholera virus were 

 produced under licenses. 



Inspectors of the division inspected and admitted 442,878 hogs 

 and 1,504 calves to the premises of licensed establishments for use 

 in the production and testing of serum and virus, while 70 hogs were 

 rejected on inspection. In subsequent inspections 25,989 hogs were 

 rejected on account of conditions which made them unsuitable for 

 the production or testing of licensed products. 



During the year 856,358,652 cubic centimeters of anti-hog-cholera 

 serum were produced by licensed establishments. Of this quantity, 

 143,996,700 cubic centimeters consisted of clarified serum. The 

 quantity of hyperimmune blood and serum in an incomplete form 

 destroyed under supervision amounted to 3,896,425 cubic centimeters, 

 while the quantity of serum in a completed form destroyed amounted 

 to 6,737,459 cubic centimeters. The quantity of simultaneous virus 

 produced was 36,221,820 cubic centimeters, while 535,090 cubic centi- 

 meters in incompleted form and 892,758 cubic centimeters after 

 being completed for marketing were destroyed. The quantity of 

 hyperimmunizing virus produced was 182,827,682 cubic centimeters, 

 of which 8,053,150 cubic centimeters was destroyed at the time of 

 collection and 373,675 cubic centimeters after preparation. In addi- 

 tion 713,708 cubic centimeters of inoculating virus was produced. 



