REPORT OF THE SECRETARY. 55 



that morphiii sulphate used in hypodermic tablets is usually adulter- 

 ated with codein. The caffein investigations have been continued 

 with special reference to certain factors modifying toxicity, such as 

 starvation, variation of temperature, and fatigue. The action of 

 caffein on the circulation, with special note of the drugs modifying 

 its effect, has been studied extensively. 



The total number of samples examined during the year is 1,544, of 

 which 294 were of synthetic products, 49 of essential oils, and 392 of 

 chemical reagents. 



INSPECTION OF FOOD AND DRUGS. 



INIore than 10.000 official samples of foods and drugs were collected 

 by the inspecting force of the bureau during the past year. Ap- 

 proximately 1,500 factory inspections were made to secure informa- 

 tion on the sanitary conditions of the establishments and the gen- 

 eral practices as they affect the enforcement of the food and drugs 

 act. The samples were referred to the inspection laboratories in 

 Washington and the 22 branch laboratories in different sections of 

 the country, where analyses were made to learn whether the products 

 were being sold in compliance with the law. 



In addition to the original analyses made for inspection or investi- 

 gation work, check analyses were made and cases were prepared for 

 the consideration of the Board of Food and Drug Inspection in the 

 Washington laboratories of the bureau. The Drug-Inspection Labor- 

 atory reported 809 samples examined, of which G04 w-ere domestic 

 products. Of these, 132 (22 per cent) were found to be either 

 adulterated or misbranded or both. The Food-Inspection Laboratory 

 reported the study, of approximately 5,000 analytical reports of 

 domestic samples, most of which were by the branch laboratories. 

 In 2,034 instances the reports showed violations of the law, and cases 

 were prepared for the consideration of the Board of Food and Drug 

 Inspection. About 7.800 analytical reports on the import food cases 

 were considered, in addition to 741 special cases, 558 of which were 

 reported to the Treasury Department as representing adulteration or 

 misbranding under the act and 183 were recommended to the Secre- 

 tary of Agriculture for release. 



Other executive work in connection with the food and drugs act 

 is the distribution of check samples, the receiving and recording of 

 food samples sent to Washington, and the care of seeing that the 

 proper exhibits are sent to the United States attorney concerned in 

 each of the cases reported for prosecution. 



WATERS. 



Mineral and table waters as found at source and as they appear on 

 the market have been examined. As a result of the examination of 



