32 



Litcrature on Inosite-Phosphoric Acid 



[Sept. 



HO-^P— O— Q 

 Ho/ 



H 

 -C— 0-P' 





/^ 



-OH 

 \0H 



(3) 



P_0— CH HC— 0— Pf 



HO 

 O^ 



=0 



v\0H 



sOH 



hq// 



;P— O— c- 



h 



-C— O— P= 



h 



=0 



\\0H 



HO/ \0H 



M. W., 660; C = 10.91%; P = 28.18%. 



Neuberg came to similar conclusions the following year when he 

 obtained inosite and furfurol on mixing " phytin " with phosphoric 

 acid and distilling under reduced pressure, and also showed that 

 furfurol can be obtained from inosite. He proposed the following 

 f ormula : 



H 



-c- 



(4) 



HO. 



H0\ H 



HO>P-0-(; 



HO^. 



HO-7P— O— CH HC— O 



HO/ 



H 



/OH 



O— ^<0H 



/OH 

 -P.^OH 



\0H 



t 



-CH 



HO— P\ /P— OH 

 HO/ ^0^ \0H 



M. W., 714;C = 10.085% ; P = 26.05%. 



Levene, working with a preparation from hempseed, was led to 

 believe that the "phytin" of this grain contained in its molecule 

 phosphate, inosite and a carbohydrate of the pentose group. His 

 work was criticized by Neuberg, who claimed that there were 

 impurities in the preparation. In view of the known intimate asso- 

 ciation of the phytin with protein and carbohydrate in the aleuron 

 grain, and the possible occurrence of a chemical combination of 

 both phyto-phosphate and carbohydrate with protein, it is conceiv- 

 able that Levene had a product holding pentose as an integral part 



