igi2] William J. Gies 63 



ing Condom was supported in the neck of the bottle by a tightly 

 fitting cork Stopper, which also served to keep the bag closed. After 

 a diffusion period of convenient length (sometimes 2 to 5 days)/^ 

 the Condom was cautiously removed from the bottle, the ether diffus- 

 ate was poured into a porcelain dish, and the ether completely re- 

 moved by evaporation on a steam bath. At least one appropriate 

 test was then applied to the residue.^^ 



Meanwhile, the ether Solution in the Condom was removed. A 

 large volume of water was then poured into the suspended bag, 

 which, during its distention by the water, was carefully examined 

 for signs of leakage. In a few instances defective membranes tem- 

 porarily rendered the outcome doubtful. All results with such bags 

 were ignored, of course. Each of the tests, even after reliable pos- 

 itive responses, was repeated at least once with a nezv rubber bag. 



The substances named below (the complete list of those already 

 tested in this connection) are readily diffusible under the conditions 

 of these experiments : — 



A. Apomorphin, atropin, brucin, caffein, Cocain, codein, col- 

 chicin, coniin, morphin, narcein, narcotin, nicotin, physostigmin, 

 quinin, strychnin, veratrin. 



B. Acetanilid, antipyrin, phenacetin, picric acid, picrotoxin, 

 pyramidon, salicylic acid. 



Experiments with other solvents, and with additional substances 

 of alkaloidal type, will be added to this series. 



" Some of the alkaloids pass through rubber almost immediately under the 

 conditions of these experiments. 



*' In the experiments with nicotin, the " tobacco odor " of the concentrated 

 liquids was very pronounced. 



