A STUDY OF SOME PROTEIN COMPOUNDS 



WALTER H. EDDY 



(Biochemical Laboratory of Columbia University, at the College of Physicians 



and Surgeons, New York) 



Contents. (A) Morphin mucoid, 112; (B) strychnin mucoid, 114; (C) conin 

 mucoid, 115; (D) piperidin mucoid, 115 ; (E) anilin mucoid, 115; (F) morphin 

 nucleoprotein, 115; (G) morphin caseinogen, 116, strychnin caseinogen, 116, 

 calcium caseinogen, 116; (H) strychnin ovo-mucoid, 117; (I) histon mucoid, 

 118; (J) histon nucleoprotein, 121; (K) histon ovo-mucoid, 121. 



I. INTRODUCTION 



When I began Ph.D. work in this laboratory, six years ago, 

 Dr. Gies was actively engaged in studies of the properties of various 

 protein Compounds which he had prepared as early as 1904.^ He 

 inaugurated that work from the Standpoint of his interest in the 

 chemical composition of protoplasm, and the nature of the struc- 

 tural and dynamic relationships of cell constituents and products. 

 He believed that the knowledge gained from studies of artificial 

 protein Compounds would pave the way for successful inquiry into 

 the nature of the protein correlations in the cells — relationships of 

 the most fundamental biological character. At his Suggestion, and 

 in furtherance of this object, I have conducted the experiments de- 

 scribed in this paper.^ 



The general plan of the research was: (A) The production of 

 protein salts by combining organic hases, such as strychnin, mor- 

 phin, conin, piperidin, etc., with acid-reacting proteins, such as 

 tendo-mucoid, ovo-mucoid, yeast nucleoprotein, etc.; and {B) the 

 production of protein salts by combining hasic proteins, such as 



^Gies: Proc. See. Path. and Physiol., Amer. Med. Assn., 1906, p. 121. 



''The detailed results of this work have been described in the writer's 

 dissertation, On the synthesis of some protein salts, Columbia University, 1909 

 (pp. 61). A preliminary report was published by Eddy and Gies in the Pro- 

 ceedings of the Society for Experimental Biology and Medicine, 1907, iv, pp. 

 I4S-6. 



III 



