EFFECTS OF INTRAPERITONEAL INJECTIONS OF 



EPINEPHRIN ON THE PARTITION OF NITRO- 



GEN IN URINE FROM A DOG 



JACOB ROSENBLOOM and WILLIAM WEINBERGER 



(Biochemical Laboratory of Columbia University, at the College of Physicians 



and Surgeons, New York) 



I. INTRODUCTION 



The action of epinephrin on nitrogenous metabolism has been 

 the object of investigation by several authors. The experimental 

 results of Kraus and Hirsch/ and Quest,^ indicate that intravenous 

 or subcutaneous injections of epinephrin exert very Httle influenae 

 on the nitrogenous metaboHsm of healthy dogs, the insignificant 

 increase of eliminated nitrogen being caused both by the glycosuria 

 and (after subcutaneous injections) by skin necrosis. Fasting ani- 

 mals seem to be differently affected. Falta and Rudinger,^ and 

 Underhill and Closson* were able to show an accelerating influ- 

 enae, on protein metaboHsm, of subcutaneous and intravenous injec- 

 tions of epinephrin. 



Underhill and Closson have shown that the subcutaneous injec- 

 tion of " adrenalin chlorid " Solutions into dogs is not attended by 

 any significant change in the proportions of the urea-, ammonia- and 

 creatinin-nitrogen of the urine, in partial disagreement with Paton,^ 

 who also found that, although on a sufficient diet, the catabolism of 

 proteins is not interfered with, there is a markedly increased produc- 

 tion of ammonia. 



In all the above mentioned experiments the epinephrin was in- 

 jected into veins or into subcutaneous tissues. The intraperi- 

 toneal way has not been utilized by previous observers in this con- 



^ Kraus and Hirsch. Cited by Kraus and Friedenthal : Berl. klin. Woch., 

 1908, xlv, p. 1709. 



^Quest: Zeit. f. exp. Path., 1908, v, p. 43. 

 ' Falta and Rudinger : Central, f. klin. Med., 1908, Ixvi, p. i. 

 * Underhill and Closson : Anier. Journ. Physiol., 1906, xvii, p. 42. 

 ' Paten : English Journ. of Physiol., 1903, xxix, p. 286 ; 1904, xxxii, p. 59. 



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