13Ö Biochemical Proceedings, Hygienic Congress [Sept. 



hour when it beglns to fall. In one instance the heat production 

 during a morning hour was 22.3 calories, and after the ingestion of 

 1,200 grams of meat it had risen in the second hour to 36 calories, 

 reaching 40 calories in the third hour at which level it remained 

 through the tenth hour, after which it gradually feil to 25 calories 

 in the twenty-first hour. During the second hour the nitrogen elim- 

 ination was one third the maximal nitrogen Output as evenly main- 

 tained between the third and tenth hours. The second hour also 

 showed that the calculated non-protein respiratory quotient ranged 

 between 90 and 99, which indicated that that part of the metabolism 

 which was not due to protein, as calculated from urinary nitrogen, 

 originated largely from carbohydrate. During the later hours, the 

 increased heat production is proportional to the nitrogen in the urine. 

 During a period of 15 hours, protein carbon was retained in the or- 

 ganism and when the oxygen absorption as computed on the basis 

 of such retention in the form of dextrose is compared with the 

 actual oxygen absorption, the two agree within 0.9 per cent., 

 whereas computed on the basis of carbon retained as fat, there is a 

 discrepancy of 10 per cent. between the calculated and actual value. 

 Administration of 50 grams of dextrose in 150 c.c. of water to a 

 dog causes a rise of heat production from 16.2 to 20 calories, at 

 which level it is maintained during the second, third and fourth 

 hours, falling nearly to the basal level in the fifth hour. The skin 

 temperature rises to a greater extent than the rectal temperature. 

 The absorption from the intestine is completed in the fourth hour. 

 The urine is scanty until the fourth hour when 100 c.c. are suddenly 

 eliminated. The sugar content of the blood in per cent. rises in 

 the first hour but becomes normal after that. After the first hour 

 the percentage of hemoglobin in the blood falls but returns to nor- 

 mal subsequent to the fourth hour. Hence, after sugar ingestion, 

 osmotic phenomena cause an increased volume of blood. When the 

 absorption is complete, the glycogenic function removes the dex- 

 trose from the blood, and the blood returns to its normal composi- 

 tion through the elimination of water by the kidney. Water alone 

 or a Solution of salt or of urea have no effect on the metabolism, 

 hence the increase in metabolism is probably due to the increased 

 number of molecules of dextrose carried to the cells and not to 



