I9I2] Alfred P. Lothrop i59 



animals, the Symptoms were identical with those observed after in- 

 jections of /8-imidazolylethylamin. There was no delay in coagu- 

 lation of the blood, but there was marked lowering of blood pres- 

 sure and lowering of body temperature. 



After intravenous injections of filtered giiinea pig iirine into 

 three dogs, Symptoms resembUng those of anaphylactic shock were 

 exhibited, but the fall in blood pressure was not constant as it is 

 after anaphylactic shock, and there was no delay in the coagulation 

 of the blood. There is evidently some relation between the occur- 

 rence of putrefactive amins and anaphylactic shock, but the writer's 

 results do not bear out Pfeiffer's opinion regarding that relation. 



5. On the physiological action of some of the amins produced 

 by intestinal putref action. Allan C. Eustis. (Laboratory of 

 Clinical Medicine, Department of Nutrition, Tulane University, 

 New Orleans, La.) Putrescin (tetramethylendiamin) and cada- 

 verin (pentamethylendiamin), in doses as small as o.i mg., are in- 

 stantly fatal when injected intravenously into guinea pigs. Non- 

 fatal doses produce marked lowering of blood pressure, dyspnea 

 from edem.a of the lungs, salivation and prostration. The pulse is 

 quickened. 



Phenylethylamin is immediately fatal to a guinea pig weighing 

 300 gm. when 0.05 gram is injected intravenously; 0.03 gram was 

 fatal in two minutes when injected intravenously into a 300 gram 

 guinea pig, with immediate prostration and paralysis of the respira- 

 tory center ; 0.02 gm. produced a distinct chill in a 300 gram guinea 

 pig, followed by prostration but with ultimate recovery. 



ß-imidasolylethylamin, in doses of o.oi gram intravenously, 

 caused death in three minutes with typical anaphylactic Symptoms, 

 the animals dying in attacks of forcible inspiratory effort, the heart 

 continuing to beat after the respiration had ceased. 



Parahydroxyethylamin, as well as isoamylamin, produced marked 

 rise in blood pressure. 



6. Solubilities and action of /?-imidazolylethylamin and the 

 relation to asthma and anaphylaxis. Allan C. Eustis. (Lab- 

 oratory of Clinical Medicine, Department of Nutrition, Tiüane 

 University, New Orleans, La.) I. A specimen of chemically pure 

 )S-imidazolylethylamin, obtained through the courtesy of Dr. Dale 



