164 Proceedings Coliunbia Biochemical Association [Sept. 



larger yield of milk. The percentage of fat in the milk fluctuated 

 regularly with the changing amount of phosphorus ingested. The 

 response was immediate, but the quantities of milk-fat bear no con- 

 stant ratio to the amount of phosphorus in the rations. Aside from 

 those pertaining to the fat, there were practically no changes in the 

 composition of the milk, not even in the percentage of phosphorus 

 in the fat-free solid matter. 



The moisture relations in the problem seem significant, though 

 the intake and outgo of water could not be accurately measured in 

 this experiment. The margin, after allowing for the influence of 

 temperature, leads one to suspect a large retention of water in the 

 last two periods. 



Up to the sixtieth day there was no outward sign of any physio- 

 logical disturbance, but about that time the appetite began to wane. 

 On the seventy-seventh day the milk-flow declined rapidly and 

 serious trouble developed. A few days later the cow was placed 

 in a box-stall and fed alfalfa, silage and vvheat bran, which caused 

 all signs of malnutrition to disappear in the course of a week and 

 also increased the milk-flow. 



IL ABSTRACTS OF PAPERS FROM THE COLUMBIA BIOCHEMICAL 

 DEPARTMENT AND AFFILIATED LABORATORIES 



11. Contribution to the knowledge of nucleoprotein metab- 

 olism, with special reference to uricolysis and to the properties 

 of uricase.^ David Alperin. The author studied the relative 

 efficiency of the Wiener, Rosell, Croftan, Wiener and Wiechowski, 

 and Galeotti methods for the preparation of uricase, and indicated 

 the properties of the products. Wiener and Wiechowski have sug- 

 gested that the subcutaneous or intravenous administration of 

 uricase preparations is an effective procedure for the eure of gout 

 and allied diseases. The author concludes that "practical demon- 

 stration of the efficiency of this method of treatment has not been 

 made." 



12. The comparative diffusibility of various pigments in 

 different solvents. George D. Beal and George A. Geiger. 

 (Piiblishcd in füll in this issue of the Biochemical Bulletin.)^ 



"Alperin: Dissertation, Columbia University, 1912. 



'Beal and Geiger: Biochemical Bulletin, 1912, ii, pp. ydr-^. 



