I9I3] Alfred P. Lot Itrop 453 



B of the convulsiva action of potas- 



Max Kahn. The calcium content of ^ ^^J!^"^ sulfocyanate. (71) 



tuberculous areas in lung tissue. R- Ottenberg, D. J. Kaliski and S. S. 



/„ -v Friedman. Expenmental agglutina- 



Charles C. Lieb. On the localization ^ive and hemolytic transfusions. 



(72) 



A. ABSTRACTS OF PAPERS ON RESEARCH BY NON-RESIDENT 



MEMBERS* 



63. Resistance in tuberculosis. Jacob J. Bronfenbrenner 

 and W. H. Manwaring. (Rockefellcr Institute for Medical Re- 

 search, Nczv York City.) Tubercle bacilli, injected into the 

 peritoneal cavities of tuberculous guinea-pigs, occasionally de- 

 generate and develop into the non-acid resistant forms described by 

 Deycke and Much,^ and others. Under certain conditions, there 

 may be a complete disappearance of the bacilli from the peritoneal 

 fluids within as short a period of time as three hours. 



Whether this disappearance is due to an actual lysis of the 

 tubercle bacilli, or to other causes, we have not yet determined. 

 As evidence in favor of lysis we have observed that all of the normal 

 control guinea pigs, injected intraperitoneally with the test suspen- 

 sions of tubercle bacilli, died from a fulminating type of visceral 

 tuberculosis, within a period of from three to four weeks, while 

 most of the tuberculous guinea pigs, receiving the same test doses, 

 have survived for longer periods of time A few of these tubercu- 

 lous guinea pigs, however, have died within twenty-four hours after 

 the intraperitoneal tests, suggesting an anaphylactic reaction. We 

 have obtained a similar rapid disappearance of tubercle bacilli from 

 the peritoneal cavities of tuberculous rabbits, from tuberculous rats, 

 and from tuberculous dogs. 



The question now arose as to the mechanism of this heightened 

 peritoneal resistance. From the similarity between this phenome- 

 non and the Pfeiffer reaction attempts were made to determine 

 whether or not the specific antibodies, upon which the intraperitoneal 



*Members of the Association who were not officially connected with the 

 Columbia Biochemical Department when the research was conducted. 



* Deycke and Much : Beitrag s. Klinik f. Tuberk., 1910, xv, p. 277; Much 

 and Leschre: Ibid., 1911, xx, p. 405; Kraus and Hofer: Deutsch, med. Wochen- 

 schr., 1912, xxxviii, p. 1227; Wiener klin. Wochenschr., 1912, xxv, p. 1112. 



