1913] Alfred P. Lothrop 461 



Natural (as distinguished from immune) iso-agglutination is, how- 

 ever, a relatively weak phenomenon. 



Iso-hemolysis and iso-agglutination are closely connected with 

 each other in dogs, as Moss and others have shown them to be in 

 human blood. In our observations hemolysis never occurred with- 

 out agglutination. Apparently iso-hemolysins may be developed 

 de novo by the repeated transfusion of agglutinable cells, but they 

 are never developed by the transfusion of non-agglutinable cells. 



Hemolysis in the body of a dog is far more intense than in the 

 test-tube. (The authors have made the same Observation in the 

 case of a human transfusion which has not yet been published, and 

 similar experimental observations have been made by Muir and 

 M'Nee.) 



The direct transfusion of blood whose red cells can be agglu- 

 tinated and laked by the recipient's serum is followed by destruction 

 of the transfused blood, with an intense intoxication. It is not 

 yet clear whether agglutination plays any part in this result, or 

 whether it is due entirely to hemolysis. 



A very remarkable blood-picture, presenting many of the 

 morphological forms peculiar to pernicious anemia, is produced 

 when the blood of another animal of the same species is destroyed 

 in the circulation. (Similar blood-pictures have been observed by 

 Bunting and others to follow anemia produced by hemolytic 

 poisons). In our experiments this was not due to anemia, as the 

 animal's own blood was not destroyed, and there was no reason to 

 believe they were anemic. The changes must have been due to 

 some peculiar toxic efifect, on the bone-marrow, of hemolytic blood 

 destruction. 



II. TENTH MEETING 



The tenth scientific meeting of the Association was held at the 

 Columbia Medical School, at 4.15 p. m., on April 4, 1913. The 

 summary on page 462 facilitates reference to the abstracts (73-85) 

 of the papers presented. 



