122 Colchicine 



TABLE 4.5 

 Action of Colchicine on Bacteria 



Species Results Reference 



Agrobocterium spp growth not inhibited 4-35 



Bacillus mesentericus size increase 40%, growth changes 4-113 



Bacterium megatherium negative results 4-149 



Bacterium spp no action 4-66 



Bacterium spp indecisive results 4-43 



"Bacteria" no action 4-1 44 



"Coliform bacteria" mutations 4-109 



Escherichia coli polynuclear cells 4-134 



E. coli phage 4-25 



Micrococcus spp inactive 4-19 



M. aureus negative results 4-19 



Micrococcus spp morphological changes 4~1 49 



M. aureus respiration inhibited 4-1 7 



Mycobacterium tuberculosis stimulates cells, prevents variants 4-63 



Photobacterium phosphorcum growth increases 4-104 



Proteus vulgaris inhibition 4-37 



Streptococcus catarrhaiis toxic action 4-^^49 



S. hernolyticus inhibition 4-37 



Camphor induced giantlike cells now called the "camphor forms." 

 In old cultmes these appear with low frequency. A few were found 

 after treatment with colchicine, but their frequency was not high 

 enough to warrant the conclusion that colchicine had the same 

 capacity as camphor to produce giant forms.^ 



In light of the known antagonistic action of ethanol as discovered 

 for cells of Allium, the jjroduction of alcohol by the yeast cell itself 

 may serve as a kind of antidote or protection against colchicine. ^2 

 These facts have not been verified with experimental data. 



Brewing tests did not bring out specific differences between treated 

 and control cidtures of Stuc haroinyces cercTlsiae.^- The usual sedi- 

 mentation, foam head, and other comparative values revealed no 



