726 Colchicine 



TABLE 4.7 

 Action of Colchicine on Protozoa 



Species Results Reference 



Amoeba proteits fission not inhibited with 2% solution 4-71 



.1. sphaeronucleus microinjection inhibits division of nucleus 4-20 



Chilomonas spp fission not inhibited . 4-71 



Chlamydomonas spp not effective on division 4-49 



4-83 

 4-144 



Chlamrdomonas spp growth retarded 4-24 



Euslena spp ineffective 4-71 



4-144 

 4-83 



Oxytncha spp no action 4-71 



Paramecium spp raising temperature increases toxic action 



of colchicine 4-58 



P. caudatum fission not retarded 4-71 



P. caudatum growth retarded 4-3 



P. caudatum radiosensitivity increased 4-57 



P. multimicromicleatum no action 4-71 



Peranema fission 4-71 



Plasmodium relictum no retarding action 4-1 1 



P. vivax no action 4-1 1 8 



anatomical variations are probably a direct action from the drug by 

 other means than nuclear changes. ^^•'^ As an example, the c-tumor 

 response occurs from contact with colchicine. Yet more difficult to 

 exjjlain are the changes that persist into several generations of propa- 

 gation."**^' Vegetati^e propagations that continue the anatomical varia- 

 tions are not as difficult to explain as \ariations that reportedly 

 persist or occur after several generations of seed propagation. 



Not so much attention has been directed to the cell wall and re- 

 lated problems of differentiation as to nuclear aspects, i.e., c-mitosis.^'^ 

 Colchicine causes modification of cytoplasmic and cellular processes.^-^^ 

 Sufficient evidence is at hand to make this assumption. The actions 

 of c-mitosis, the c-timior, and differentiation are independent al- 

 though very closely related to each other. For example, the nearly 



