780 



Colchicine 



acetylcholine were ob,ser\ed. There was no true neuromuscular block. 

 Anesthetic properties have also been descril:)ed; these are probably 

 of central origin. Death often follows a period resemblino narcosis. 

 In the dog, this apj^ears before the muscle paralysis. In cold-l)looded 

 animals, the nervous changes may be very slow to appear. In frogs 



RECTAL TEMP. 

 98° F_ 



COLCHICINE : 2 MGM. PER KGM. 



36°C.- 



35°- 



34°_ 



97' 



96< 



95= 



94° 



93< 



92' 



10 



20 



SO 



CORTIN 



NaCl+NaCit 



40HRS. 50 



Fig. 7.2 — Action of cortin and sodium on the temperature fall of rats after colchicine 



intoxication. (After Clark and Barnes ') 



kept at low temperature, reflexes disa|)pear progressi\eh, the corneal 

 being the last, and this not until sexeral weeks after an injection of 

 colchicine.-" 



7.5-2; Striated tnusdr. Recent studies of the frog's sartorius muscle 

 have brought ne^\^ evidence of a muscidar action of colchicine. In 187.5, 

 irreversible changes in striated muscles of frogs injected with a large 

 dose were first reported.-" Later "owcolchic ine" was showu to be 



