Pharmacology 187 



30000 r 



.leukocytes ( total ) 



-.lymphocytes 



. granulocytes 



25.000 _ 



20.000 _ 



15.000^ 



10.000 



5.000 



hours: o 10 20 30 40 50 60 70 80 90 



Fig. 7.7— Modifications of the leukocyte count of a dog injected 0.34 mg kg colchicine. 



(After Dixon and Maiden"') 



In a later paper,-i j, j^ nRiitioncd tliai after repeated injections ol 

 colcliicine in rabbits, "sections of smears ol the bone-niarroAv . . . 

 exhibit proliferation . . . : j^lrtitifiil mitotic forms (tni orcasionaUy be 

 obsen'cd" [our italics].* 



There can be no doubt toda\ that the sionificance ol these his- 

 tological changes was not grasped. These pui)li( ations on colchicine 

 pharniacologv were widely quoted, and Un 2t) vears text books 



* ]our. Piiysiol.. ;?7(1908), p. 7(i. 



