192 



Colchicine 



ZOO - 



CD 

 

 O 



LJJ 



LL 

 O 



a: 



UJ 



D 

 Z 



150 



100 



— •— COLCHICINE 



— O- CONTROL 



HRS 



Fig. 7.8 — Action of colchicine on the release of eggs from the ovary of the frog, 

 treated in vitro with pituitary powder. (After McPhail and Wilbur") 



have been observed in liver cells. These will be discussed in the next 

 paragraph. After se\eral injections of colchicine, man\ arrested 

 mitoses are to be seen. The stages of recovery lead often to bizarre 

 nuclei which may resemble those of megakaryocytes. Cellular damage 

 may not be evident at all, and the cause of these divisions is not clear. 

 A hormonal stimulation related to stress and the adaptation svndrome 

 is possible. •''■'■ 



