270 Colchicine 



jected with colchicine, no skin tumors appeared."^- This result is 

 contradicted by experiments demonstrating that methylcholanthrene 

 tumors appeared in 30 days in mice injected with colchicine.*'^ The 

 time for the controls was 100 days. There is no evidence trom the data 

 of the literature that colchicine may be itself a carcinogen. 



REFERENCES 



1. Amoroso, E. C. Colchicine and tumour growth. Nature. 135:266-67. 1935. 



2. Andfrvont, H. B. Effect of colchicine and bacterial products on transplantable 

 and spontaneous tumors in mice. Jour. Nat. Cancer Inst. 1:361-63. 1940. 



3. AsTALDi. G.. AND Mairi. C. Recherchc sur I'activitc prolifcrati\e de I'hemocvto- 

 blaste de la leucemie aigue. Rev. Beige Path. 23:(i9-82. 1953. 



4. Bass, A. D., and Probert, C. Response of a transplantable lymphosarcoma to 

 colchicine. Cancer Res. 10:420-22. 1950. 



5. Bernardelli, E., Rondanelli, E. G., and Gorini, P. Ricerca suH'attivita pro- 

 liferativa e differenziativa deU'eritroblasto della ijolicitemia vera. Haemato- 

 logica. 36:891-906. 1952. 



6. Bernelli-Zazzera, A. Contributo alia conoscenza dei fattori co-cancerogeni e 

 del lore, mecanism d'azione sulla cute del topo. Tumori. 38:339-50. 1952. 



7. Bloch-Fr.ankenthal, L., and Black, A. Effect of colchicine on tumor growth 

 and tumor pyrophosphatase. Proc. Soc. Exp. Biol, and Med. 76:105-9. 1951. 



8. BouRG, R., and Dustin, P., Jr. Le traitement des papillomes vulvaires par 

 I'application locale de colchicine. Presse Med. 43:578. 1945. 



9. Bovland, E., and Bovland, M. E. Studies on tissue metabolism. IX. The 

 action of colchicine and B. txphosus extract. Biochem. Jour. 31:454-60. 1937. 

 Studies on tissue metabolism. XII. The action of colchicine on transplanted, 

 induced and spontaneous mouse tumors. Biochem. Jour. 34:280-84. 1940. 



10. Branch, C. F., Fogg, L. C, and Ullyott, G. E. Colchicine and colchicine-like 

 compounds as chemotherapeutic agents. Acta Unio Internat. Cancrum. 6: 

 439-47. 1949. 



11. Brodersen. H. Mitosegifte und ionisierende Strahlung. Strahlenther. 73: 

 196-254. 1943. 



12. Brown, W. O. Effect of colchicine on human tissues. Arch. Path. 29:865-66. 

 1940. 



13. BRiicKE, E. T. v., and Hijber, E. v. tiber die erfolgreiche Behandhmg emer 

 Krebsnietastase mit Colchicin und Rontgenbestrahlung. Klin. Wschr. 18: 

 1160-61. 1939. 



14. Brues, a. M., Marble. B. B.. and Jackson, E. B. Effects of colchicine on growth 

 of normal tissues and tumors. Amcr. Jour. Cancer. 38:159-68. 1940. 



15. Brumfield, R. T. Effect of colchicine pre-treatment on the frequency of 

 chromosomal aberrations induced by X-radiation. Proc. Nat. Acad. Sci. 29: 

 190-93. 1943. 



16 Carr J. G. The effect of some substances influencing cell activity upon the 

 growth of the Rous n° 1 sarcoma. Brit. Jour. Exp. Path. 23:221-28. 1942. 



17. Chevallier, p., and Colin. M. Vaste epithelioma Ijasocellulaire traitc locale- 

 ment par la colchicine. Ann. Soc. Fran^. Dermat. Syph. 6:297-98. 1946. 



18. Clearkin, p. a. The effect of colchicine on normal ami neoplastic tissues in 

 mice. Jour. Path. Bact. 44:469. 1937. 



19. Dermen, H., and Brown, N. A. A cytological study of the effect of colchicine 

 on plant tumors. Amer. jour. Cancer. 38:169-90. 1940. 



20. Denlssenko. p. Traitement de la carcinose par lusage interne ct les appli- 

 cations locales dextrait de chclidoine. .Semaine Med. ((luoted in Menetrier, 

 see Ref. 50.) 1896. 



21. Dickinson, L., and Thompson, M. J. Chemotherapeutic investigations with 

 Rous sarcoma virus. Brit. Jour. Piiarmacol. 7:277-86. 1952. 



22. Downing, V., Hartwell, J. L., Leitlr, J., and Shear, M. J. Effect of a single 

 injection of colchicine, colchicine deri\atives and rchited compounds on mouse 

 tumors. Cancer. Res. 9:598. 1949. 



