Subject Index 447 



trisomies, 345-47 

 in Tiibifex, 53 



I'inra pollen mother cells, 349 

 watermelon, 329-31 

 X and y, 352-54 

 Chronica Botanica, 287 

 Ciba, of Basel, Switzerland, 143 

 Cinematography, 67, 91, 378 

 Cladnphora, 119 

 Cleavage, 87 



in eggs, 202, 203, 204 

 Cloacal epithelium, 226, 227 

 Clonal division method, 300 

 Closterium, 119 

 Cliii) root disease 



in radish, 370 

 Cokhicamide, 409 

 Cokhiceinamide, 409 



Cokhiceine, CiH.sOeN, 14, 16, 160-61, 

 167-69, 171, 404, 408,411 

 singularity, 420 

 structures, 168 

 tautomerides, 168 

 yields isomeric methyl ethers, 168 

 Colchicine 

 action of 

 algae, 124 

 Arbacia, 74-75 

 blood level, 196 

 circulation, 193-94 

 cleavage, 87-89, 202-3 

 differentiation processes, 125-27 

 feathers. 190-93 

 heart, 138 

 kidney, 191-93 

 liver, 191 

 liverworts, 1 18 

 meiosis, 110-17 

 mosses, 117 

 nervous system, 179 

 spindle. 65-98 

 striated muscle, 180-81 

 advantages o\er other agents, 275 

 agar impregnation, 377 

 Allium treated, 34, 41 

 anaphase, 45 



anatomical changes in plants, 129-31 

 anesthetic properties, ISO 

 and anticarcinogens, 269 

 archesporial tissue, 110 

 bacteria treated with, 121 

 biological properties, 373 

 bivalents of c-meiosis in jilants. 1 10 

 cancer chemotherapy, 265 

 carbon-labeled derivatives of. 171. 196 

 cell plates inhibited, 89, 90 

 cell size, 103 



chemical action concept of, 403-16 

 cliemistry of, 15. 159-74 

 chromosomal pairs, 28, 37, 41, 43, 49 

 chronic intoxication after re|)eated in- 

 jections, 193 



in mice, 189 

 in rabbits, 187-88 

 classified disturbances on spindle, 86 

 clea\age processes, 75, 87-89 

 compountls of, 144—48, 153-54 

 concentration. 383 

 conversion of spindle form, 65 

 critical time-dose relation of, 34 

 crystallization of. 159 

 derivatives of, 15-17, 111-47, 159-74, 



394 

 destruction of spindle fibers, 69-78 

 effect of temperature. 374 



toxicity, 194 

 effect on bacterial enzymes, 417 

 effect on enzyme reactions. 131 



diastase, 131-32 

 elimination of 

 bile, 196 



in excretions, 194 

 intestine. 196 

 embryonic growth, 209-1 1 

 e\olution of cpairs. 49 

 experimental gro\\ th, 214-19 

 fad in research, 16. 21, 274 

 fate in animal body, 195-96 

 fixation in tissues. 245-55 

 gonads. 202-3 

 gout treated by, 196-98 

 hormotie-mimetic actions, 190-91 

 induced mutant seedlings, 55 

 and induction of: 



amphiploidv. 292-311 

 aneuploid. 345-47 

 autoploidv, 318-33 

 chimeras, 348-51, 384 

 polyploidy, 274-75 

 inhibition of spindle, 68 

 inhibition of fall of complexes of acto- 



myosin, 420 

 interaction with, at molecular level, 65 

 intramedullary injections, 264 

 leucocvtosis after, 183, 185, 189 

 light effects on solutions of, 154, 374 

 local applications of 

 on embryo, 209 

 on tumor, 263 

 male gametes changed by, 204-5 

 malformations in chickens bv. 206. 207, 



208 

 mechanism of reactions upon mitosis, 



391-421 

 megaspore mother cells, 1 10 

 meiosis following, 103. 110 

 metabolism effects induced b\ , 191 96, 



395-96 

 methylation of, 171 

 mutagenesis by, 275. 318 

 named, 14 



neoplastic growth changed bv 

 iir animals, 214-47 

 in plants, 269 



