134 ANNUAL REPORT OF THE Off. Doc. 



Approximate amount of serum in stock December 



31, 1913, 232050 C. CM. 



Amount produced during 1914, 665860 " 



Approximate amount disposed of during 1914, .... 720460 '' 



Approximate amount in stock December 31, 1914, . . 177450 " 



Amount produced during 1915 606900 " 



Approximate amount used during 1915, 652050 " 



Amount in stock December 31, 1915, 132300 " 



There is no doubt but what hog cholera and other diseases have 

 been spread by the injudicious use of vaccination. T"p to the present 

 time the Board has been able to produce a sufficient amount of 

 serum to meet the demands. It has been distributed free of ex- 

 pense to the owner. There is no occasion for our people to purchase 

 serum and take the chance of getting a product that is impotent or 

 that may be the means of spreading this or some other dangerous 

 disease. 



It is pretty well understood that there is no medicine on the market 

 that will cure hog cholera and there are no proprietary medicines 

 that will prevent it. During the year considerable was heard about 

 an advertised prevention and cure known as "544." This was pre- 

 pared and sold by the Theile Laboratories of Columbus, Ohio. So 

 much was heard about this new treatment that it was decided ad- 

 visable for the Board to test its merits. 



Three hogs were taken. No. 4919, No. 4920 and No. 4921, weighing 

 ]20, 115 and 60 pounds respectively. Hog No. 4919 received 6 c. c. ; 

 No. 4920, 5i c. c, and No. 4921, 3 c. c. of "544" intramuscularly; 

 this being the proportionate dose recommended in the sheet of in- 

 structions as an immunizing dose for well hogs. They were in- 

 jected on October 2, 1914, at which time the temperatures were 

 101.4, 100.4 and 102 respectively. They were then placed in an in- 

 fection pen, and between October 8th and October 14th showed 

 clinical symptoms of hog cholera— diarrhoea, dullness, decreased or 

 loss of appetite, more or less reddening of the skin, and weak and 

 .'staggering gait — while the temperatures In that time had risen to 

 106 degrees and ranged between that and 107 until October 15, when 

 they were killed for virus. 



In the pen with these animals Avere placed three other hogs. No. 

 4922, No. 4923, No. 4924, as check or control animals on the three 

 treated hogs. These weighed 118, 60 and 58 pounds respectively. 

 No. 4922 and No. 4923 became sick, showed dullness, diarrhoea and 

 temperatures of 105.8 and 106.2 on October 9th. On October 10, 

 they were both given "544" to try to prove its curative value. No. 



4922 received 12 c. c. and No. 4923 6 c. c. intamuscularly. No. 4924 

 showed a rise in temperature to 106.2 degrees on the 10 of October. 

 On the 11, showed 106.4 and on the 12th 106.1 when it was given 6 

 c. c. of "544" intramuscularly. No. 4922 died October 13th, No. 



4923 was killed October 15th for virus. No. 4924 died October 17th. 

 All six of these animals were carefully autopsied and showed typi- 

 cal postmortem., lesions of hog cliolera, including enlarged and 

 hemorragic lymph glands, enlarged spleen with subscapular hem- 

 orrliages, hemorrhagic areas in the lungs, T>etechiated kidneys; hem- 

 orrhagic inflammation of the stomacli and intestines, and in some 

 of the cases beginning ulceration around the ileocaecal vale and in 

 the large intestines. 



