168 STATE BOARD OF AGRICULTURE. 



calves. In this horn is a dead fetus about six centimeters in length. The 

 fetal membranes are shrunken, appear as a fattened band about 85 centi- 

 meters in length by six millimeters wide. The mucosa of left horn is 

 moist and glistening, is a veal flesh color and it is not possible with the 

 naked eye to distinguish the regions of the cotyledons. The right horn 

 is smaller than the left and contains about ten cc. of a creamy yellow 

 exudate. The mucosa shows no cotyledons and is similar in appearance 

 to that of the left. 



There is no enlargement of either oviduct. The left ovary has a full 

 size corpus luteum and two cysts ten and fifteen millimeters in diameter 

 respectively. 



Streptococcus viridans was isolated from the uterus. 



Histological examination : In the mucosa of the left horn there is con- 

 siderable edemia of the stroma. The uterine glands are dilated as in 

 pregnancy. Occasionally the epithelium lining the pits shows slight 

 granular degeneration. In forty-seven sections studied from six different 

 portions of the left horn no cotyledons are observed. At one point there 

 are observed a few arterioles grouped in the sub epithelial tissue, sug- 

 gesting a cotyledon but here there is an absence of the characteristic 

 tissue of the cotyledon. 



Whether the apparent sterility and death of the fetus was due to the 

 absence of maternal cotyledons cannot be answered at this time. The 

 placental epithelium is phagocytic and it seems that attachment might 

 occur at any point of the mucosa. On the other hand the gland mucosa 

 does not possess the rich vascular supply near the surface that the 

 cotyledon possesses and it may be that the chorionic villi do not find an 

 adequate blood supply when attachment is made to the gland mucosa. 

 Possibly the rich blood supph^ of the cotjdedon accounts for the positive 

 chemotaxis of the cotyledon for the chorionic villus. 



In the mucosa of the right horn tliefe are no marked alterations. 



In a few places tlie nuclei of the epithelium are faintly stained and in 

 a few other places slight granular degeneration of the epithelium is seen. 

 The glandular epithelium of a few of the glands show slight mucoid 

 changes. 



There are no alterations of the oviducts other than near the fundlis it 

 appears that there may be an excessive number of lymphocytes entangled 

 within the cilia of the epithelium. 



Cow No. 6312 — was an aged cow (exact age and past breeding record 

 not definitely known). Her last calf was February 10, 1920. She had 

 been persistently bred since then but failed to conceive. During the last 

 half of the year 1921 she Avas bred as follows: May 27th, June 17th, 

 August 9th, September Gth and October 2nd. Cow was slaughtered 

 December 13th, 1921. 



Macroscopic examination : The ventral portion of the first fold of 

 cervical mucosa is considerably hypertrophied and shows numerous cj^sts 

 varying in size from one-half to three millimeters in diameter. There is 

 a tenacious mucus in cervical canal. The uterine horns are not enlarged. 

 The uterine mucosa is not uniform in color. The region of the cotyledon is 

 a brownish red color with numerous small grayish yellow focci. The gland 

 mucosa is a grayish brown color. Both oviducts are about twice their 

 normal size. There are no fibrous constrictions in the oviducts. 



