EXPERIMENT STATION BULLETINS. 609 



iodoform-bismiith-oil preparation were injected into uterus. This treatment 

 was continued at weekly intervals for the next three or four weeks vnth. but 

 little improvement. During the first week of August this cow had a fracture 

 of the pelvis and no further treatment was given. She was slaughtered on 

 September 14, 1919. 



Macroscopic Examination: Dorsal and to the right of the bifurcation of 

 the uterus there is a sharply circumscribed encapsulated abscess about seven 

 centimeters in diameter, containing a thick creamy granular pus. This 

 abscess communicates with the posterior end of the right horn by a small 

 canal directed backward. There is a small quantity of mucus in external os 

 containing but a few flakes of pus. The mucosa of the cervix is a fairly uni- 

 form light drab color. There is some hypertrophy of the second transverse 

 fold of the cervix. The left horn is somewhat larger than the right and con- 

 tains about four fluid ounces of a sero-purulent exudate. The gland mucosa 

 of the uterine bodj'^ and left horn is mottled and varies in color from that of 

 a yellowish gray to a reddish bro^vn. There are distributed over the mucosa 

 some twelve to fifteen small cyst-like structures projecting slightly above the 

 surface and varying from one to three millimeters in diameter. These appear 

 to contain a clear fluid. In addition to these there are a larger number of 

 small circumscribed areas varying in size from one to two millimeters in 

 diameter, the center of which appears as a dark gray spot varying from one 

 half to one mm. in diameter, surrounded by a small peripheral zone appar- 

 enth^ containing a clear fluid. The cotyledons vary in size from three by 

 eight mm. to six by ten mm. ; the}- are of a lighter color than that of the gland 

 mucosa. The cotyledons bear some resemblance to pig's liver, the lobules of 

 which are extremely fatty. These light yellow lobule-like areas vary in size 

 from that of a pin point to one mm. in diameter. The mucosa of the right 

 horn is of a more uniform yelloT\ish gray color than that of the left horn. 

 The cotyledons are a lighter color and are about one half the size of those of 

 the left horn. The right ovary is six centimeters in diameter and has three 

 well marked cysts fifteen to eighteen mm. in diameter. A non-motile gram 

 negative gas producing rod of the colon group was isolated from the uterine 

 exudate. 



Histological Examination : The mucosa of the uterine body and left horn is 

 three to four mm. thick and is covered with epithelium averaging about six- 

 teen microns high. Most of the epithelial cells show very poorly stained or 

 unstained nuclei. There is a marked leucocytic infiltration and proliferation 

 of fibroblasts throughout the stroma but the resulting density is greater 

 toward the mucous surface than toward the muscularis. The glandular 

 changes are not marked although a few leucocytes are seen in some of the 

 gland tubules. There are many oval shaped cysts in the mucosa varying in 

 size from four-tenths by eight-tenths mm. to two by tour mm. These cysts 

 are lined with colunmar epithelium averaging about twelve microns high and 

 the connective tissue just without has been modified to produce a definite 

 cyst wall. Some of the cotyledons are covered watli a stratified squamous 

 epithelium consisting of five or six layers, the outer layer or two of which ap- 

 pears to be cornified. The stroma of the cotyledon is more densely infiltrated 

 with leucocytes and endothelial cells than is the stroma of the gland mucosa. 

 The mottled appearance of the cotyledons described in gross is apparently 

 due to the marked leucocytic and endothehal cell infiltration of the stroma. 

 That is, normally, the minute blood vessels of the cotyledon are arranged in 

 several groups containing three or four vessels in some groups to as many as 



