EXPERIMENT STATION BULLETINS. 611 



in the denuded areas, the necrosis extending to a depth of fifty to sixty mi- 

 crons. There is a marked leucocytic infiltration of the superficial portion of 

 the stroma. Here lymphocytes predominate although numerous fibroblasts 

 and plasma cells are seen. The glandular lesions are not marked though in 

 many of the gland tubules detached eipthelial cells and leucocytes are seen 

 and in places the peri-glandular tissue is more cellular than in others. 



There is a superficial dijEfuse necrosis of the cotyledons averaging about one- 

 half mm. in depth. The crypts are poorly defined. What remains of them 

 appear as irregular areas more or less filled with detached epithelial cells, 

 placental cells and leucocytes. Occasionally there appear in the crypts what 

 may be taken as the remains of a chorionic tuft. The crypts exiend to a 

 depth of two to two and one-half mm. 



The mucosa of the left horn only differs from that of the right in that there 

 is apparently more normal epithelium. In places, however, the same super- 

 ficial necrosis and leucocytic infiltration is observed. 



Case No. 29 



History and Clinical Examination: Guernsey cow about eight years old. 

 Her previous breeding record is unknown. She calved at full time March 28, 

 1920 and retained the afterbirth. Two days later the attending veterinarian 

 attempted to remove it but could remove only a part of it. The uterus was 

 irrigated with physiological sodium chloride solution and then one dram of 

 iodoform, two drams of bismuth subnitrate suspended in two ounces of 

 mineral oil was injected into the uterus. Two days later more of the after- 

 birth was taken away and the same treatment given as noted above. On 

 April fifth it is recorded that the pulse and respiration are increased, there is 

 a loss of appetite, diarrhea, and the animal is in a very weak condition. More 

 of the afterbirth is removed and the same treatment given as noted above. 

 Stimulative treatment is begun on this date. On April sixth there is a puru- 

 lent discharge in vagina but the uterus is apparently free of afterbirth. There 

 is no improvement in the general condition of the animal. The daily vaginal 

 (antiseptic douch) and stimulative treatment is continued with no improve- 

 ment in the general condition. On April thirteenth symptoms of pneumonia 

 appear. Animal continues to grow worse and is killed on April nineteenth 

 on account of a moribund condition due to a bilateral lobar pneumonia. 



Macroscopic Examination: There is a small quantity of muco-purulent 

 exudate in the anterior part of vagina and cervical canal. The cervical canal 

 is nine cm. in length. The mucosa is of a fairly uniform yellowish gray color 

 except at the crest of the folds where it is shghtly injected. The left lateral 

 portion of the first transverse fold of cervical mucosa is slightly hypertrophied 

 and slightly injected. The uterine body is five cm. in length and the mucosa 

 is covered with a thin layer of a thick adhesive purulent exudate. On scrap- 

 ing this away the mucosa is seen to be of a mottled steel gray color with a few 

 bluish black areas that appear to be old hemorrhages. The left horn is about 

 twice the size of the normal horn of a non-pregnant cow that has had one or 

 more calves. The wall varies in thickness from six mm. at the posterior end 

 to three mm. at the middle and anterior end. The mucosa of the posterior 

 end is of a dirty yellow uniform color except near the base of the cotyledons ; 

 here the mucosa has a pinkish tinge. The appearance of the mucosa changes 

 toward the middle of the horn, particularly near the base of the cotyledons, 

 where there is a thin, but not uniform adhesive purulent exudate adherent 

 to the cotyledons and parts of the gland mucosa. The gland mucosa is of a 



