EXPERIMENT STATION BULLETINS. 613 



epithelium is apparently normal. In that portion of the mucosa showing 

 regeneration of the epithelium the sub-epithelial zone does not show a marked 

 leucocytic infiltration. The stroma is more dense than the normal uterine 

 stroma; this is more apparent toward the epithelium than toward the mus- 

 cularis; numerous endothelial cells and fibroblasts are seen. 



The mucosa of the middle portion of the left horn averages about two and 

 one-half mm. in thickness. In places there is a superficial necrosis averaging 

 sixty-five microns in depth. In other places no necrosis is observed but the 

 mucosa is bare of epithelium and still in others the mucosa is covered by re- 

 generated epithelium. The peculiar appearance of the mucosa described in 

 gross is due to the swollen condition of the mucosa between the gland ducts. 

 This swelling is the result of a leucocytic infiltration of the stroma, prolifera- 

 tion of the endothelial cells and fibroblasts and the new formation of capil- 

 laries. These changes are more marked in the outer portion of the stroma 

 and diminish rapidly toward the deeper portions. The orifices of the gland 

 ducts are filled with a pinkish granular detritis in which numerous leucocytes, 

 erythrocytes and a few epithelial cells are seen. In the region of the cotyle- 

 dons the necrosis is more uniform and there are numerous petechial hemor- 

 rhages in the superficial portions. In the anterior end of the left horn, the 

 necrotic zone, where it has not sloughed off averages about one hundred and 

 fifty microns deep. At places however, it dips down into the stroma to a 

 depth of one-half to seven-tenths of a mm. giving rise to minute ulcers. There 

 is apparently a greater proportion of fibroblasts in the sub-necrotic stroma 

 than in the middle portion of the horn. 



Case No. 30 



History and Clinical Examination: Cow about nine years old, aborted a 

 seven months old fetus September 27th, 1920. The afterbirth was retained 

 and removed by attending veterinarian. On September 29th there were 

 symptoms of pneumonia and a putrid discharge from uterus. She was placed 

 on stimulative treatment and one ounce of boric acid was introduced into 

 uterus. Uterus was irrigated on the 30th and a boric acid capsule introduced 

 into uterus on October 4th. After this only vaginal treatment was given 

 locally and the stimulative treatment continued. The animal progressively 

 got weaker and died on the night of October 24th, 1920. Autopsy demon- 

 strated a septic embolic pneumonia, suppurative mammitis and purulent 

 endometritis. 



Macroscopic Examination : The external cervix is covered with a thick 

 gray purulent exudate. The first fold of the cervical mucosa is highly con^ 

 gested and hypertrophied. Cervical canal is seven cm. in length. The 

 mucosa is of a steel gray color. Body of uterus is three cm. in length and the 

 mucosa is covered with a thick gray pus. On scraping this away the mucosa 

 is seen to be of a steel gray color. The right horn is about twice the size of a 

 non-pregnant normal horn; the mucosa is covered with a thick gray pus in 

 which is seen numerous small brownish black granules about the size of a 

 mustard seed, probably precipitated constituents of blood. The appearance 

 of the gland mucosa is similar to that of the uterine body. The cotyledons 

 average about eight by twelve mm. and project above the surface six to eight 

 mm. They are of a steel gray but lighter color than that of the gland mucosa. 

 There is a thick gray purulent exudate adherent to the surface. 



The left horn is but slightly enlarged. The mucosa is similar to that of the 



