EXPERIMENT STATION BULLETINS. 617 



Histological Examination: The cervical mucosa shows numerous sub- 

 epithelial hemorrhages at the crest of the folds. Here the epithelium in places 

 is denuded, at others it is well stained even in places where there are numerous 

 sub-epithelial hemorrhages. In the pits between the folds, the mucosa shows 

 no effects of treatment. The uterine mucosa to a depth of about two-tenths 

 mm. shows a distinct zone in which the capillaries are engorged and there is 

 marked edema. The superficial epithelium is cloudy and more granular than 

 normal but the nuclei are well stained. 



Case No. 3 



Clinical Condition and Treatment: Cervical secretions abundant as in 

 heat. Cervical mucosa slightly congested and canal open. No abnormality 

 of uterus or ovaries could be detected, chnically. One ounce of Lugol's solu- 

 tion of iodine diluted with one ounce of water was injected into uterus and the 

 cervix was swabbed with undiluted Lugol's solution. The cow was slaugh- 

 tered twenty-nine hours after treatment. 



Macroscopic Examination : On the dorsal surface of the posterior end of 

 the right horn is a circumscribed slightly raised yellowish gray area sur- 

 rounded by a hemorrhagic zone. This lesion is two and one-half by five cm. 

 in size. There is about one teaspoonful of a muco-fibrinous exudate, in exter- 

 nal OS. The cervical mucosa is highly congested and shows numerous petechial 

 hemorrhages, especially along the dorsal surface. There are about three 

 ounces of a straw colored serous exudate in uterine cavity. In addition to 

 this there are two muco-fibrinous clots, the larger of which begins in the right 

 horn and extends around into the left horn. It is about twenty cm. in length, 

 irregularly cylindrical and a little larger than a lead pencil. 



Near the middle of the left horn there is a small amount of coagulated 

 blood. The uterine mucosa is congested, more marked in the right than the 

 left horn. The mucosa over the circumscribed lesion described above is 

 roughened and of a greenish tinge. On section of this lesion a sero-sanguineous 

 clot twelve mm. in diameter is seen in the deeper layers of the uterine wall 

 (hematoma) . 



Histological Examination : The alterations in the cervical mucosa are not 

 general but are confined to the crest of the folds. Here there is a more, or less 

 diffuse hemorrhagic zone the average depth of which is about one hundred 

 and fifty microns. The epithelial changes over these areas, while marked are 

 not extensive. At places they are shrunken to one-half their normal height 

 and many of them show no nuclei, at other places where there are extensive 

 sub-epithelial hemorrhages the epithelium shows no changes. In a few 

 scattered areas the epithelium is denuded. The sub-epithelial capillaries are 

 engorged and there are many diffuse sub-epithelial hemorrhages. There is 

 no well marked leucocytic infiltration of the hemorrhagic areas although in a 

 few small areas there appears to be a slight increase in the number of leu- 

 cocytes. There is but little evidence of reaction on the part of the fixed con- 

 nective tissue cells in the hemorrhagic areas. In the pits formed by the folds 

 and in the tubular depressions the mucosa shows no changes. 



There is a superficial necrosis of the uterine mucosa, involving in most 

 places only the superficial epithelium. In a few places however, the necrotic 

 process dips down into the stroma. The epitJielium is denuded in places, 

 where present it varies from six to twenty microns in height and the nuclei 

 ^re unstained. In places there is a sub-epithelial zone varying in depth from 



