624 STATE BOARD OF AGRICULTURE. 



the mucoid changes are well marked, in others they are absent. The sub- 

 epithelial zone is but slightly cellular. The mucosa of uterine body varies in 

 thickness from one and one-half mm. (in scar like area) to three mm. and is 

 covered by an epithelium twelve to fourteen microns in height. The epithelium 

 over the scar like area shows marked mucoid changes. Here the stroma is 

 very dense and contains no glands. In the other portions of the uterine 

 mucosa the sub-epithelial cellular zone is not distinct but is distinctly more 

 fibrous than normal. There is a conspicuous diminution in the number of 

 glands. Areas of a square mm. or more are seen in which there are no glands. 

 However, numerous glands are seen with apparently normal epithelium. At 

 one point, between a vein and artery, is seen a focus of transitional fibroblasts 

 four hundred eighty by eight hundred microns in size. The mucosa of the 

 horns varies from three to seven mm. in thickness and is covered by an 

 epithelium ten to sixteen microns in height. In the epithelium are seen a few 

 oval shaped cyst-like structures averaging eight bj' sixteen microns in size 

 and containing a yellowish granular substance. The sub-epithelial zone is 

 denser and slightly more cellular than the deeper portion of the stroma but 

 the differentiation is not so distinct as in the normal uterus. There is a di- 

 minution in the number of glands and many glands with atrophic epithelium 

 are seen but there are also many apparently normal glands. The peri- 

 glandular tissue in general is slightly more cellular than the interglandular 

 tissue, giving rise to the appearance observed in gross. 



It was surprising to the writer that more fibrosis of the uterine mucosa with 

 atrophy of the epithelium had not resulted from the pyometra and drastic 

 treatment that had been administered. 



SUMMARY 



t 



The injection of one ounce of Lugol's solution of iodine either undiluted 

 or diluted wdth an equal volume of water, into the uterine cavity 

 of the cow produces an acute fibrinous endometritis with superficial 

 necrosis of the mucosa varying in depth from twenty microns to 

 one millimeter. Injection of one or two ounces of menthol-iodine- 

 glycerine has the same effect. Marked superficial necrosis is apparent 

 the day following injection and sloughing of the necrosed tissue by a process 

 of liquefaction necrosis is observed in forty-eight hours after treatment. 

 Regeneration of the epithelium may be observed as early as seventy-eight 

 hours after treatment, resulting in the partial covering of the eroded surface 

 before the necrotic zone is completely detatched. This covering of epithelium 

 results from a proliferation of the epithelium lining the gland ducts in case the 

 superficial epithelium has been completely destroyed. Other than marked 

 edema and engorgement of the blood vessels there is but little evidence of the 

 effects of such treatment upon the deeper portions of the uterine mucosa. 

 Out of ten cases treated there were three in which the treatment apparently 

 caused the rupture of a blood vessel resulting in a hematoma. In one of these 

 the cow was in heat, in another there was evidence of menstruation and the 

 third was pregnant. In view of the fact that in each of these conditions there 

 is an engorgement of the blood vessels, the thought is suggested that such 

 treatment about the time of estrum or menstruation may be a dangerous 

 practice. 



The effects of swabbing the cervical mucosa with concentrated preparations 

 -of iodine are limited almost entirely to the crest of the folds. Here there is 

 more pr. less necrosis of the epithelium with riecrpsis, and capillary hemor- 



