EXPERIMENT STATION BULLETINS. 



625 



rhages in the sub-epithelial tissue. In the pits and in the tube-hke depressions 

 there is little or no effects of treatment. The results illustrate that it is im- 

 possible to disinfect, even the surface of the cervical mucosa by the application 

 of such preparations. Where beneficial results follow such treatment it is 

 more likely that the good results are due to the inflammatory reaction of the 

 tissues rather than to the destruction of bacteria. The inflammatory reaction 

 is the expression of the mechanism of defense and repair in which more blood, 

 meaning more leucoc3i;es, more bactericidal substances, and more nutrition, 

 are brought to the part. This with the greater activity of the tissues to over- 

 come the destruction wrought by the drug incidentally overcomes the in- 

 fection. 



The condition found in cases seven, eight and nine indicate that repair is 

 more or less complete in about two weeks from treatment. There is but 

 slight, if any, evidence that any appreciable fibrosis results from one treat- 

 ment of this nature. The thought is suggested by these observations that 

 less fibrosis is likely to result from such treatment than might result from 

 milder irritation over a longer period of time. 



Grateful acknowledgment is here given to Prof. R. H. Pettit and Miss 

 Eugenia ]\IcDaniel of the Department of Entomology for making the photo- 

 micrographs illustrating this bulletin. 



Plate I. 



Fig. 

 Fig. 



Plate 11. 

 Fig. 



EXPLANATION OP PLATES 



1. Case No. 27. Cysts in the uterine mucosa; X 10. 



2. Case No. 27. Stratified and cornified epithelium over a 



cotyledon; X 200. 



. Case No. 28. Superficial necrosis of cotyledon in pyometra 

 ten days after aborting. The crypts are poorly defined ; X 72. 



Fig. 4. Case No. 29. Uterine mucosa. Superficial necrosis, a, and 

 leucoc}i:ic infiltration, b, of gland mucosa. In the process of 

 healing sloughing would take place at c ; X 72. 



Plate III. 



Fig. 



Case No. 30. Superficial necrosis and leucocytic infiltration 

 of gland mucosa. At a, a thrombus is seen in a bloodvessel; 

 X72. 



Fig. 6. Case No. 30. Superficial necrosis and leucocytic infiltration of 

 both the region of the cotyledon and gland mucosa. At a, 

 and b, thrombi are seen in vessels; X 72. 



Plate IV. 

 Fig. 7. 



Case No. 3. Cervical mucosa twenty-nine hours after treat- 

 ment with Lugol's solution of iodine diluted with an equal 

 volume of water. At the crest of the folds, a, the epithelium 

 is shrunken and poorly stained. There are numerous 

 petechial hemorrhages in the subepithelial tissue, b. In the 

 pits, c, no effect of the treatment is seen; X 72. 



