THE ALUMNI JOURNAL. 



^5 



SYNTHETIC REMEDIES. 



By VIRGIL COBLliNTZ, Ph.D., 

 Professor of Theory and Practice of Pharmacy. Director of the Pharmaceutical Laboratory. 



"T^HE following comprises a resume of 

 the more important synthetic reme- 

 dies.introduced during the past year. 



Alumnol— Aluminium salt of nap- 

 thol-sulfonic acid. A fine powder, very 

 soluble, employed for antiseptic dress- 

 ings; non-poisonous when employed ex- 

 ternally; dissolves in purulent discharges, 

 hence does not stop up wounds. 



Amido-antipyrine — Antipyretic, 

 more soluble than antipyrine. 



AnTispasmin — ^A preparation consist- 

 ing of one molecule of narceine sodium 

 combined with 3 mol. sodium salicylate; 

 contains about ^0% narceine. A very 

 soluble and pure form of narceine. Recom- 

 mended as hypnotic and sedative. Dose 

 0.006 to o. I gms. 



AsAPROL — -A soluble derivative of 

 /^-napthol, sulfonic ether of /:/-napthoI, 

 as calcium salt, white powder, very solu- 

 ble; resembles soda salicylate as antisep- 

 tic, and as remedy in acute articular 

 rheumatism. Dose same as the sali- 

 cylate. 



Bismuth Phenates — Among a group 

 of antiseptic combinations of Bismuth, 

 the following are more important; Phenol 

 Bismuth — Cresol Bi.<".muth — Tribrom phe- 

 nol Bismuth — Chlorphenol Bismuth — 

 Resorcin Bismuth and Beta-napthol Bis- 

 muth. These form neutral, inodorous, 

 tasteless powders of red, yellow and 

 white colors; insoluble in water. Among 

 these, the Napthol Bismuth has found 

 application in treatment of the first stages 

 of cholera, dose 2 gms. In the intestines 



it is split up into Beta-napthol, which is 

 eliminated through the kidneys, and 

 Bismuth Oxide- The Tribrom-phenol 

 Bismuth is recommended as an intestinal 

 antiseptic; forms a yellow colored, neu- 

 tral, insoluble powder, containing 50% 

 Tribrom-phenol; said to be almost a 

 specific against choler.i-bacilli. Dose 

 5 to 7 gms. 



Benzo PARA-CRESOL — Prepared by ac- 



tion of benzoyl chlo- 

 ride on the soda salt 

 of para-cresol. In- 

 soluble in water. 

 Soluble in ether and 

 hot alcohol. Proper- 

 ties antiseptic. 



C CH3 



/A 



HC CH 



I II 

 HC CH 



V 



C— CO-CeH, 



Caffeine Chloral — A mixture of 

 the two in molecular proportions. Ad- 

 ministered hypodermically in doses of 0.2 

 to 0.4 gms. in relieving habitual consti- 

 pation. 



Chloraloxime — V. Heyden prepared 

 a new class of compounds from chloral 

 and oximes : 



H=NOH + CCL COH=CCK 



COH 

 ( ON=H 



This body on being heated with water 

 separates its chloral. Recommended as 

 hypnotic. 



Chloralose — An hydro-gluco -choral. 

 Prepared by Harinot from anhydrous 

 chloral and glucose; crystalline, sparing- 

 ly soluble in cold, and very soluble in 

 alcohol and hot water. Hypnotic action 

 greater than chloral, showed no toxic 

 properties. Dose of 0.5 gms. produced 



