40 



THE ALUMNI JOURNAL. 



accounted for by the comparative insolu- 

 bilitj^ of the latter, it being much slower 

 absorbed by the system. Knorr cites 

 among examples of tautomerism in the 

 pyrazol series, three forms of phenyl- 

 methyl-pyrazolon thus : 



which contain ethyl groups are active, 

 and the intensity of the effect of these 

 depends on the number of ethyl groups 

 contained in the molecule." A disulfon 

 containing one ethyl group 



NH 



HCII 



II 

 HC 



q 



|N ^ 

 1-1 



CH 



N— CeH, 



0=C| ||N 

 ^ H,C C— CH 



Methylene 

 Formula. 



N— C.Hb 



/\ 

 0=C| jNH Imid Formula. 



I I 

 HC==C— CH3 



N— CeHs 



/\ 



OHCll 1|N Phenol Form. 



HC" 



'C— CH, 



from these he prepared six different 

 methyl derivatives. The alkyl deriva- 

 tives ot the phenol forms show no trace 

 of antipyretic action, w^hile those of the 

 methylene and imid formula including 

 antipyrin, all possessed well defined anti- 

 febrile properties. 



HYPNOTICS. 



In this division the amido group does 

 not play any important part. Many of 

 these are derivatives of carbamic acid, 



NH. 



C=0 



-OH 



the ethers being called ure- 



'NH, 



thanes ; the ethyl ether C^^O 



--0— C,Hs* 



forms the excellent hypnotic urelhane. 



Some vtry interesting work has been 

 performed by Baumann* who compared 

 the physiological action of sulfonal to 

 bodies of similar constitution, the Disul- 

 fones. ' ' Among the disulfones only those 



*Z. Phys. Chera. XIV-52. 



tWritten either {Q.VL^)^=Q.={i,0^(i^Yi^\^ or (C2H5)j=C 

 —(SOzCHa), the same may besaidof the other disulfones. 



( 



'^^^^>C<gQ;_^2;;) produces an 



effect only half as intense as that of one 

 containing two ethyl groups (sulfonal)t 



CH.-^^^SOa— C.Hs 



Again sulfonal 



is far less powerful than trional, a disul- 

 fon containing three ethyl groups 



-C^Hs 

 -C2H5 



The most power- 



ful of them all is tetronal, a disulfon con- 

 taining four ethyl groups, thus 



CoH5^,,^^P^^SO., — C2H5 

 CHs-^ ^SO^— C,H5 



A disulfone 



containing four methyl groups is without 

 medicinal effect. In certain configura- 

 tions the ethyl group plays a certain 

 pharmacological part, which under like 

 circumstances is not shown by the ?nethyl 

 group. In the above instance the com- 

 parison affords us valuable conclusions. 

 To illustrate the vast difference in their 

 effect on the system, Baumann adminis- 

 tered doses of 1.5 gms. pro kilo of the 

 four fold methylated disulfon without 

 any visible effect, while a dose as small 

 as 0.3 gms. pro kilo of the tetronal (four- 

 fold ethylated disulfon) produced power- 

 ful toxic effects. 



SOME DIFFERENT AMIDO DERIVATIVES. 



There are a number of bodies in which 

 the amido group does not play the prin- 

 cipal part in the therapeutic effect, but 

 assists materially in the production of 

 more soluble compounds and le.ssens the 

 toxic effect of the body. Here we have 

 the uric-acid solvent piperazin 



