75 



Fig. 45. — -Diagram of the life-cycle of Plasmodium cynomolgi ; that of P. vivax 

 is now known to be similar. — From Shortt. Trans. Roy. Soc. trap. Med. Hyg., 

 1948. 42, 227. 



1, Sporozoites from salivary glands of mosquito enter liver cells. 



2. Liver cell containing early stage of pre-erythrocytic parasite. 



3 and 4. Stages in development of the pre-erythrocytic schizont in liver cells. 



5. Fully developed pre-erythrocytic schizont rupturing and releasing pre-erythrocytic merozoites. 



6. Liver cell containing merozoite of exo-erythrocytic cycle of schizogony. 



7-9. Remaining stages in exo-erythrocytic schizogony ending in second generation of merozoites. 

 10. Red cell of circulating blood. 



11-14. Stages in erythrocytic schizogony in circulating blood. 

 15, Fully developed erythrocytic schizont rupturing and releasing erythrocytic merozoites and 



gamonts. 

 16-20. Repetition of erythrocytic schizogonv. 

 21-22. Development of male gamont in circulating blood. 

 23-24. Development of female gamont in circulating blood. 



25. Wall of stomach of mosquito. 



26. Exflagellating male gamont producing microgametes in stomach of mosquito. 



27. Female gamont extruding polar bodies and so becoming a macrogamete. 



28. Microgamete free in stomach o J mosquito and seeking macrogamete. 



29. Zygote. 



30. Ookinete about to penetrate epithelium of stomach. 



31. Oocyst lying under elastic membrane on outer surface of stomach. 

 32-33. Stages in development of oocyst with production of sporozoites. 



34. Rupture of mature oocyst with dispersion of sporozoites. 



35. Salivary gland of mosquito containing mature sporozoites. 



