64 



C. U. C. P. ALUMNI JOURNAL 



tic crystals of calcium oxalate will be 

 shown under a magnifying power of 

 from 200 to 300 diameters. 



(b) 50 cc. of wine are mixed at 

 room temperature, with 2.50 cc. of a 

 5% solution of calcium chloride, 2.50 

 cc. of 99% acetic acid and 5 cc. of a 

 saturated solution of sodium acetate. 



This mixture is set aside for 24 hours, 

 and after shaking, is centrifuged. If 

 oxalic acid is present, this will be 

 shown microscopically. The authors 

 claim this method will show the presence 

 of oxalic acid if as little as o.oi in 1,000 

 is present. 



Active Constituents of Squill. 



Kopaczewski describes two active con- 

 stituents which he succeeded in isolat- 

 ing in the pure form from Scilla mar- 

 itinia. One of these he calls scillitin. 

 stating that it is an active poison. The 

 other he calls scillidiuretin, stating that 

 he found this constituent to be strongly 

 diuretic in action. This latter constitu- 

 ent would seem to be identical with the 

 substance described by Mand-et under the 

 name of scillitin. Scihitin (Kopaczewski) 

 is a permanent yellow powder, possess- 

 ing a very bitter taste. It is sparingly 

 soluble in water (0.15 : 100), the solu- 

 tion possessing a neutral reaction. It is 

 more soluble in alcohol. The author be- 

 lieves it to be a chemical unit, a non- 

 nitrogen containing glucoside having the 

 following formula : Ci-HogOg. He ob- 

 tained from 2 to 3.70 grammes of the 

 substance from one kilo-gramme of the 

 drug, o.ooi gramme of scillitin repre- 

 sents the poisonous activity of about i 

 gramme of the clried drug. 



Scillidiuretin occurs in the form of an 

 amorphous, yellow powder. It is quite 

 soluble in water, but practically insoluble 

 in alcohol. The aqueous solution pos- 

 sesses an astringent taste. Experiments 

 on animals showed that it is capable of 

 increasing the amount of urine very ma- 

 terially. 



Lapachol. 



Konrad Bournot, in Arch. d. Pharm., 

 2ji, states that he has obtained lapa- 

 chol from the heart-wood of Avicennia 

 tomentosa, by extraction with ether, 

 benzol or petroleum ether. The plant 

 is a member of the Verbenaceae, and is 

 found widely distributed through the 

 East and West Indies, and along the 

 western coast of Africa. This must be 

 considered a new source for lapachol. 



N EW REMEDIE S. 



Corypinol is a remedy employed in the 

 treatment of inflamed mucus membrane, 

 particularly that of the nose. It is ap- 

 plied by means of a pledget of cotton. 

 It consists of a mixture of coryfin and 

 pine oils. 



Manarsen is the name given to tablets, 

 each of which contain 0.005 &^- ^^ man- 

 ganese glycerophosphate, 0.00016 gm. of 

 arsenous acid, 0.02 gm. of extract of 

 gentian and 0.05 gm. of powdered 

 licorice root. 



Jnvenileaii. This is a preparation in- 

 tended for external use. Upon anaylsis 

 it was found to consist of an aqueous 

 solution of lead acetate 5 :ioo. 



Kahan. Under this title tablets con- 

 taining a mixture of sodium and calcium 

 lactate are marketed. 



