86 



C. U. C. P. ALUMNI JOURNAL 



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Conducted by Prof. George C. Diekman. 



Action of Chlorine on Quinine. 



A. Christensen, in Ber. d. Deutschen 

 Pharmaceutische Gesellschafft, 191 5, pre- 

 sents an exhaustive report on this sub- 

 ject, from which the fohowing is taken: 

 Chlorine water added to a sohition of 

 quinine hydrochloride, in the proportion 

 of Cl, to one molecule of quinine, forms 

 quinine oxy-chloride, C20H24CI, (OH)- 

 N2O2. If the chlorine water is added in 

 the proportion of 2CI3 to one molecule 

 of quinine, 5-chlor-6-oxycinchonin-oxy- 

 chlorid is formed, a molecule of methyl 

 alcohol splitting ofif. And if the chlorine 

 water be added in the proportion of 3CI2 

 to one quinine molecule, this will result in 

 the formation of 5-chlor-6-ketocinchonin- 

 oxy-chlorid. 



Syrupus Colae Compositus. 



The following formula and directions 

 appear in Phaym. WeekbL 1915, 821:0.20 

 gramme of quinine hydrochloride, 04 

 gramme of strychnine nitrate and 0.20 

 gramme of citric acid are dissolved in 

 sufficient distilled water to make the pro- 

 duct weight 10 grammes. Then add, 

 syrup, 150 grammes, solution of so- 

 dium glycerophosphate (50:100) 100 

 grammes, fluid extract of cola. lo.o 

 grammes, and saccharated oxide of iron, 

 15.0 gramm'es. 4 drops of oil of orange 

 peel are added to each 240 grammes of 

 the mixture, the whole thoroughly 

 shaken and finallv filtered. 



Detection of Malonic Acid. 



J. Bougoult, in Journ. Pharvi. et 

 Chtm., makes use of the property pos 

 sessed by malonic acid of forming defi- 

 nite compounds with aromatic aldehydes. 

 He also calls attention to the fact that 

 during the oxidation of many organic 

 bodies, malonic acid is formed. The 

 method is as follows: to o.io gramme 

 of malonic acid is added 15 drops of cin- 

 namic aldehyde and i mil of acetic acid. 

 The mixttire is heated in a sealed glass 

 tube, in a water-bath containing boiling 

 water, for a period of 10 hours. To the 

 hot solution are then added 15 mils of 

 water and enough sodium carbonate to 

 saturate. The solution at once assumes 

 a yellow color, and upon cooling a yellovv 

 precipitate is noted. This precipitate is 

 collected in a tared Gooch crucible and 

 dried at 100° C. o.io gramme of malonic 

 acid will yield about o.iio gram.mc of 

 cinnamyl-malonic acid. The latter has a 

 melting point of 208° C. The presence 

 of alkaline salts, niineral or organic acids, 

 as well as oxalic or succinic acid does not 

 influence the result. 



Tyrosin Crystals in Urine Sediments. 



P. Inge, in Jour, de Phar. et de 

 Chtm., comments on the frequency with 

 which investigators report the presence 

 of tyrosin crystals in urinary sediments. 

 The author during his connection with 

 the Vichy baths from 1882 until 19x3 

 had occasion to examine upwards of 31,- 

 000 samples of urine, and states that 



