THE JOURNAL OF PHARMACOLOGY. 69 



few drops of reagent, and note whether a precipitate continues to form. 

 If so, transfer the liquid just withdrawn, back to the beaker, and continue 

 adding barium chloride solution, i cubic centimeter at a time, until no 

 further precipitation occurs, upon adding a few drops of the reagent to a 

 small quantity of the clear liquid. Note the exact number of cubic cen- 

 timeters of reagent required. 



Example : When 10 cubic centimeters of reagent were added, all the 

 sulphates were not precipitated, when 11 cubic centimeters were added, 

 no further precipitation was noted when a small quantity of liquid is with- 

 drawn, indicating that perhaps the barium chloride solution was now in 

 slight excess. In this case repeat the operation, employing the same 

 quantity of urine as at first. After treating with hydrochloric acid and 

 boiling, add first 10 cubic centimeters of the reagent, and after this .2 

 cubic centimeter at a time, until complete precipitation is accomplished, 

 without using an excess of reagent. From the number of cubic centi- 

 meters of reagent employed, the quantity of sulphuric acid expressed as 

 SO3, can readily be calculated. 

 3. Estimation of neutral sulphur : 



The sample of urine is treated with sodium carbonate and sodium 

 nitrate, and evaporated to dryness. The dry residue is ashed, and the 

 ash extracted with water. This treatment converts the neutral sulphur 

 into sodium sulphate, which is extracted by the water. The solution 

 thus obtained is acidified with hydrochloric acid, and precipitated with 

 barium chloride, and then treated further as above. In another portion 

 of the same sample of urine, an estimation of total sulphuric acid is made. 

 This result is subtracted from the first result, the difference'representing 

 the sulphuric acid which was formed by the oxidation of neutral sulphur. 



(^To be continued?) 



Abstracts. 



Cocaine Poisoning. — Dr. Bergmann, Wien. klin. Woche7ischrift, March 

 8, 1900, reports a case of cocaine poisoning following the injection of 5 

 cgm., given to relieve severe pain. The results were satisfactory. The 

 day following 3 cgm. were injected with collapse, rapid heart action and 

 rapid circulation, all within three minutes. In ten minutes there were 

 clonic contractions, dilated pupils and exophthalmos. The patient re- 

 covered and the pain disappeared. 



Thrush Fungus in Gastritis. — W. A. Bastedo, Medical News, March 

 24, 1900, reports a case under observation at St. Luke's Hospital of severe 

 gastritis produced by the thrush fungus. The case occurred in a woman 

 of twenty-six years and was cured by lavage. The article is accompanied 

 by an excellent illustration. 



