Cbe 



journal of Pbarmacology, 



Devoted to the Advances Made in Materia Medica in its Branches. 



Pharmacy, Pharmacognosy, Chemistry, Botany, Pharmaco- 



Dynamics, Therapeutics and Toxicology. 



Published for the Alumni Association of the College of Pharmacy of the City of New York, 

 by The New Era Printing Company, 41 North Queen St., Lancaster, Pa. 



Vol. VII. JANUARY, 1900. No. i. 



Urine analysis by the Pharmacist. 



By George C. Diekman, Ph.G., M.D. 



(Continued from December Number.) 



PART TEN. 

 Urea. — Continued. 



2. Methods by means of which urea is estimated irrespective of other 

 nitrogenous constituents of urine. 



A. Method of Bunsen. This in outHne is as follows : 



Urine together with ammoniacal solution of barium chloride is heated 

 in a sealed tube at a temperature of 220-240°C. for 3-4 hours. The result- 

 ing carbon dioxide, in the form of barium carbonate is then estimated, and 

 from this, the urea. According to Pfliiger and Boland, the method is far 

 from exact, an error of 10% being quite possible. Salkowski employed a 

 saturated solution of barium chloride, containing in each Hter 15-20CC. of 

 a 30/0 sodium hydrate solution, estimating the ammonia thus formed, as 

 well as the carbon dioxide. 



(a) Modification of Pfliiger, Bohland and Bleibtreu. 



This consists in first treating urine with phospho-molybdic acid, when 

 all substances, other than urea, and which are capable of yielding, upon 

 decomposition, ammonia and carbon dioxide, are precipitated. This 

 method yields fairly accurate results. 



