THE JOURNAL OF PHARMACOLOGY. 267 



others as the active principles. (6) (2)' The old oils necessarily retained 

 more of their volatile constituents than the new oils, as in the process of 

 preparation of all the old medicinal oils no heat of any kind was used, 

 subsidence and pressure only being the means of expression, whereas 

 all of the new oils are subjected to a long-continued heat of about 180° 

 F., and often much above this point; thus the volatile constituents, es- 

 pecially the halogens and the phosphorus, are in a great part removed 

 in the preparation of all the modem cod-liver oil. 



Convinced of the above facts, some years ago I began to contrast 

 the therapeutic efifects of the new oils as compared with the same oil 

 fortified by the addition of iodine, bromine and phosphorus, and I was 

 soon satisfied that their addition seemed to intensify the normal thera- 

 peutic virtues of the oil. Later on, not being convinced ol the dis- 

 tinctive value of the bromine in the preparation, I omitted it, retaining 

 only the iodine and the phosphorus. 



Feeling sure of my position in this matter, I gave my formula to 

 a Philadelphia druggist with the request to so combine these elements 

 with the oil as to retain its normal pale color while endeavoring to 

 improve both the odor and palatability. 



As the result of our experiments we succeeded in producing a 

 preparation which we have designated Oleum Morrhuac lodo-Phos- 

 phoratum, a clear, light-yellow oil, flowing perhaps more freely than 

 most good oils, having less of the fishy and less of the hydroxylation 

 odor than usual and a much less marked fishy taste. Each table- 

 spoonful of this oil is fortified with one one-hundredth of a grain of 

 pure free phosphorus and one twelfth of a grain of pure free iodine, 

 neither ingredient being at all noticeable either to taste, sight or smell, 

 and yet by the method of ultimate analytical analysis all recoverable 

 therefrom. 



As having perhaps an important bearing on this question, I will 

 call attention to an alterative preparation rather extensively used in 

 our city, quite constantly by the late Dr. Pepper and by him sometimes 

 called a summer substitute for cod-liver oil. T refer to Vini lodi Comp., 

 each teaspoonful of which contains one one-hundredth of a grain of 

 free phosphorus and one-sixth of a grain each of free iodine and bro- 

 mine. It is typically an alterative. It has little or no effect upon the 

 bodily weight, except inasmuch as it stimulates growth by restoring 

 to the tissues healthy action. In no sense is it a nutrient and thus 

 differs markedly from cod-liver oil. It is extremely valuable as a 

 substitute for all those patients usually benefited by cod-liver oil, who, 

 on account of the e?ctreme heat of the summer .or a temporarily ab- 

 normal sensitiveness of the stomach-walls, or a nervous excitability 



